{[(3S,4S)-6-acetyl-4-[(3-chloro-4-fluorobenzene)amido]-2,2-dimethyl-3,4-dihydro-2H-1-benzopyran-3-yl]oxy}methyl 2-(dimethylamino)acetate

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Chemical Name:{[(3S,4S)-6-acetyl-4-[(3-chloro-4-fluorobenzene)amido]-2,2-dimethyl-3,4-dihydro-2H-1-benzopyran-3-yl]oxy}methyl 2-(dimethylamino)acetate
CAS No.:1532591-72-2
Molecular Formula:C₂₅H₂₈ClFN₂O₆
Molecular Weight:506.959
Hs Code.:

Synonyms:{[(3S,4S)-6-acetyl-4-[(3-chloro-4-fluorobenzene)amido]-2,2-dimethyl-3,4-dihydro-2H-1-benzopyran-3-yl]oxy}methyl 2-(dimethylamino)acetate

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Chemical Property of {[(3S,4S)-6-acetyl-4-[(3-chloro-4-fluorobenzene)amido]-2,2-dimethyl-3,4-dihydro-2H-1-benzopyran-3-yl]oxy}methyl 2-(dimethylamino)acetate

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Technology Process of {[(3S,4S)-6-acetyl-4-[(3-chloro-4-fluorobenzene)amido]-2,2-dimethyl-3,4-dihydro-2H-1-benzopyran-3-yl]oxy}methyl 2-(dimethylamino)acetate

There total 2 articles about {[(3S,4S)-6-acetyl-4-[(3-chloro-4-fluorobenzene)amido]-2,2-dimethyl-3,4-dihydro-2H-1-benzopyran-3-yl]oxy}methyl 2-(dimethylamino)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.9%

: 1118-68-9
dimethylaminoacetic acid

: 1532591-67-5
N-[(3S,4S)-6-acetyl-2,2-dimethyl-3-[(methylsulfanyl)methoxy]-3,4-dihydro-2H-1-benzopyran-4-yl]-3-chloro-4-fluorobenzamide

: 1532591-72-2
{[(3S,4S)-6-acetyl-4-[(3-chloro-4-fluorobenzene)amido]-2,2-dimethyl-3,4-dihydro-2H-1-benzopyran-3-yl]oxy}methyl 2-(dimethylamino)acetate

Guidance literature:: N-[(3S,4S)-6-acetyl-2,2-dimethyl-3-[(methylsulfanyl)methoxy]-3,4-dihydro-2H-1-benzopyran-4-yl]-3-chloro-4-fluorobenzamide; With sulfuryl dichloride; In dichloromethane; for 0.166667h;

dimethylaminoacetic acid; With N-ethyl-N,N-diisopropylamine; In dichloromethane; for 0.5h;

Reference yield:

: 175013-84-0
N-[(3S,4S)-6-acetyl-3-hydroxy-2,2-dimethyl-3,4-dihydro-2H-1-benzopyran-4-yl]-3-chloro-4-fluorobenzamide

: 1532591-72-2
{[(3S,4S)-6-acetyl-4-[(3-chloro-4-fluorobenzene)amido]-2,2-dimethyl-3,4-dihydro-2H-1-benzopyran-3-yl]oxy}methyl 2-(dimethylamino)acetate

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / 1,2-dimethoxyethane; mineral oil / 0.17 h

1.2: 18 h

2.1: sulfuryl dichloride / dichloromethane / 0.17 h

2.2: 0.5 h

With sulfuryl dichloride; sodium hydride; In 1,2-dimethoxyethane; dichloromethane; mineral oil;