N-[(3S,4S)-6-acetyl-2,2-dimethyl-3-[(methylsulfanyl)methoxy]-3,4-dihydro-2H-1-benzopyran-4-yl]-3-chloro-4-fluorobenzamide

Base Information

Chemical Name:N-[(3S,4S)-6-acetyl-2,2-dimethyl-3-[(methylsulfanyl)methoxy]-3,4-dihydro-2H-1-benzopyran-4-yl]-3-chloro-4-fluorobenzamide
CAS No.:1532591-67-5
Molecular Formula:C₂₂H₂₃ClFNO₄S
Molecular Weight:451.946
Hs Code.:

Synonyms:N-[(3S,4S)-6-acetyl-2,2-dimethyl-3-[(methylsulfanyl)methoxy]-3,4-dihydro-2H-1-benzopyran-4-yl]-3-chloro-4-fluorobenzamide

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Chemical Property of N-[(3S,4S)-6-acetyl-2,2-dimethyl-3-[(methylsulfanyl)methoxy]-3,4-dihydro-2H-1-benzopyran-4-yl]-3-chloro-4-fluorobenzamide

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Technology Process of N-[(3S,4S)-6-acetyl-2,2-dimethyl-3-[(methylsulfanyl)methoxy]-3,4-dihydro-2H-1-benzopyran-4-yl]-3-chloro-4-fluorobenzamide

There total 1 articles about N-[(3S,4S)-6-acetyl-2,2-dimethyl-3-[(methylsulfanyl)methoxy]-3,4-dihydro-2H-1-benzopyran-4-yl]-3-chloro-4-fluorobenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.1%

: 2373-51-5
chloro-methylsulfanyl-methane

: 175013-84-0
N-[(3S,4S)-6-acetyl-3-hydroxy-2,2-dimethyl-3,4-dihydro-2H-1-benzopyran-4-yl]-3-chloro-4-fluorobenzamide

: 1532591-67-5
N-[(3S,4S)-6-acetyl-2,2-dimethyl-3-[(methylsulfanyl)methoxy]-3,4-dihydro-2H-1-benzopyran-4-yl]-3-chloro-4-fluorobenzamide

Guidance literature:: N-[(3S,4S)-6-acetyl-3-hydroxy-2,2-dimethyl-3,4-dihydro-2H-1-benzopyran-4-yl]-3-chloro-4-fluorobenzamide; With sodium hydride; In 1,2-dimethoxyethane; mineral oil; at 20 ℃; for 0.166667h;

chloro-methylsulfanyl-methane; With sodium iodide; In 1,2-dimethoxyethane; mineral oil; at 20 ℃; for 18h;

Reference yield: 38.9%

: 1118-68-9
dimethylaminoacetic acid

: 1532591-67-5
N-[(3S,4S)-6-acetyl-2,2-dimethyl-3-[(methylsulfanyl)methoxy]-3,4-dihydro-2H-1-benzopyran-4-yl]-3-chloro-4-fluorobenzamide

: 1532591-72-2
{[(3S,4S)-6-acetyl-4-[(3-chloro-4-fluorobenzene)amido]-2,2-dimethyl-3,4-dihydro-2H-1-benzopyran-3-yl]oxy}methyl 2-(dimethylamino)acetate

Guidance literature:: N-[(3S,4S)-6-acetyl-2,2-dimethyl-3-[(methylsulfanyl)methoxy]-3,4-dihydro-2H-1-benzopyran-4-yl]-3-chloro-4-fluorobenzamide; With sulfuryl dichloride; In dichloromethane; for 0.166667h;

dimethylaminoacetic acid; With N-ethyl-N,N-diisopropylamine; In dichloromethane; for 0.5h;

Reference yield: 38.0%

: 1532591-67-5
N-[(3S,4S)-6-acetyl-2,2-dimethyl-3-[(methylsulfanyl)methoxy]-3,4-dihydro-2H-1-benzopyran-4-yl]-3-chloro-4-fluorobenzamide

: 14347-78-5,36543-79-0
1,2-O-isopropylidene-D-glycerol

: N-[(3S,4S)-6-acetyl-3-{[(2S)-2,3-dihydroxypropoxy]methoxy}-2,2-dimethyl-3,4-dihydro-2H-1-benzopyran-4-yl]-3-chloro-4-fluorobenzamide

Guidance literature:: N-[(3S,4S)-6-acetyl-2,2-dimethyl-3-[(methylsulfanyl)methoxy]-3,4-dihydro-2H-1-benzopyran-4-yl]-3-chloro-4-fluorobenzamide; 1,2-O-isopropylidene-D-glycerol; With N-iodo-succinimide; trifluorormethanesulfonic acid; In 2-methyltetrahydrofuran; at -30 ℃; for 1h;

With hydrogenchloride; In tetrahydrofuran; water; for 2h;