N-((1R,2S)-1-(4-(6-(2-amino-2-oxoethyl)pyridin-3-yl)phenyl)-3-fluoro-1-hydroxypropan-2-yl)-2,2-dichloroacetamide

Base Information

Chemical Name:N-((1R,2S)-1-(4-(6-(2-amino-2-oxoethyl)pyridin-3-yl)phenyl)-3-fluoro-1-hydroxypropan-2-yl)-2,2-dichloroacetamide
CAS No.:1582261-91-3
Molecular Formula:C₁₈H₁₈Cl₂FN₃O₃
Molecular Weight:414.264
Hs Code.:

Synonyms:N-((1R,2S)-1-(4-(6-(2-amino-2-oxoethyl)pyridin-3-yl)phenyl)-3-fluoro-1-hydroxypropan-2-yl)-2,2-dichloroacetamide

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Chemical Property of N-((1R,2S)-1-(4-(6-(2-amino-2-oxoethyl)pyridin-3-yl)phenyl)-3-fluoro-1-hydroxypropan-2-yl)-2,2-dichloroacetamide

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Technology Process of N-((1R,2S)-1-(4-(6-(2-amino-2-oxoethyl)pyridin-3-yl)phenyl)-3-fluoro-1-hydroxypropan-2-yl)-2,2-dichloroacetamide

There total 3 articles about N-((1R,2S)-1-(4-(6-(2-amino-2-oxoethyl)pyridin-3-yl)phenyl)-3-fluoro-1-hydroxypropan-2-yl)-2,2-dichloroacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1582261-90-2
2,2-dichloro-N-((1R,2S)-1-(4-(6-(cyanomethyl)pyridin-3-yl)phenyl)-3-fluoro-1-hydroxypropan-2-yl)acetamide

: 1582261-91-3
N-((1R,2S)-1-(4-(6-(2-amino-2-oxoethyl)pyridin-3-yl)phenyl)-3-fluoro-1-hydroxypropan-2-yl)-2,2-dichloroacetamide

Guidance literature:: With sulfuric acid; at 20 ℃; for 0.5h;

Reference yield:

: 927689-70-1
(1R,2S)-2-amino-3-fluoro-1-(4-iodophenyl)propan-1-ol

: 1582261-91-3
N-((1R,2S)-1-(4-(6-(2-amino-2-oxoethyl)pyridin-3-yl)phenyl)-3-fluoro-1-hydroxypropan-2-yl)-2,2-dichloroacetamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / methanol / 16 h / Reflux

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; hexamethyldistannane / toluene / 3 h / Inert atmosphere; Reflux

2.2: 4 h / 80 °C

3.1: sulfuric acid / 0.5 h / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sulfuric acid; hexamethyldistannane; triethylamine; In methanol; toluene;

Reference yield:

: 1400741-13-0
2,2-dichloro-N-((1R,2S)-3-fluoro-1-hydroxy-1-(4-iodophenyl)propan-2-yl)acetamide

: 1582261-91-3
N-((1R,2S)-1-(4-(6-(2-amino-2-oxoethyl)pyridin-3-yl)phenyl)-3-fluoro-1-hydroxypropan-2-yl)-2,2-dichloroacetamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; hexamethyldistannane / toluene / 3 h / Inert atmosphere; Reflux

1.2: 4 h / 80 °C

2.1: sulfuric acid / 0.5 h / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sulfuric acid; hexamethyldistannane; In toluene;