2-{2-[4-(3-trifluoromethylphenyl)piperazin-1-yl]-2-oxoethyl}-3a,4,5,6,7,7a-hexahydroisoindole-1,3-dione

Base Information

Chemical Name:2-{2-[4-(3-trifluoromethylphenyl)piperazin-1-yl]-2-oxoethyl}-3a,4,5,6,7,7a-hexahydroisoindole-1,3-dione
CAS No.:1334385-65-7
Molecular Formula:C₂₁H₂₄F₃N₃O₃
Molecular Weight:423.435
Hs Code.:

Synonyms:2-{2-[4-(3-trifluoromethylphenyl)piperazin-1-yl]-2-oxoethyl}-3a,4,5,6,7,7a-hexahydroisoindole-1,3-dione

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Chemical Property of 2-{2-[4-(3-trifluoromethylphenyl)piperazin-1-yl]-2-oxoethyl}-3a,4,5,6,7,7a-hexahydroisoindole-1,3-dione

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Technology Process of 2-{2-[4-(3-trifluoromethylphenyl)piperazin-1-yl]-2-oxoethyl}-3a,4,5,6,7,7a-hexahydroisoindole-1,3-dione

There total 3 articles about 2-{2-[4-(3-trifluoromethylphenyl)piperazin-1-yl]-2-oxoethyl}-3a,4,5,6,7,7a-hexahydroisoindole-1,3-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₃H₁₅N₃O₃

: 15532-75-9
1-(3-Trifluoromethylphenyl)piperazine

: 1334385-65-7
2-{2-[4-(3-trifluoromethylphenyl)piperazin-1-yl]-2-oxoethyl}-3a,4,5,6,7,7a-hexahydroisoindole-1,3-dione

Guidance literature:: In N,N-dimethyl-formamide; at 20 ℃; for 24h;
DOI:10.1016/j.ejmech.2011.07.043

Reference yield:

: 138220-90-3
2-(1,3-dioxo-3a,4,5,6,7,7a-hexahydroisoindol-2-yl)acetic acid

: 1334385-65-7
2-{2-[4-(3-trifluoromethylphenyl)piperazin-1-yl]-2-oxoethyl}-3a,4,5,6,7,7a-hexahydroisoindole-1,3-dione

Guidance literature:: Multi-step reaction with 2 steps

1: N,N-dimethyl-formamide / 0.5 h / 20 °C

2: N,N-dimethyl-formamide / 24 h / 20 °C

In N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2011.07.043

Reference yield:

: 85-42-7
1,2-Cyclohexanedicarboxylic acid-anhydride

: 1334385-65-7
2-{2-[4-(3-trifluoromethylphenyl)piperazin-1-yl]-2-oxoethyl}-3a,4,5,6,7,7a-hexahydroisoindole-1,3-dione

Guidance literature:: Multi-step reaction with 3 steps

1: water / 180 °C / Heating

2: N,N-dimethyl-formamide / 0.5 h / 20 °C

3: N,N-dimethyl-formamide / 24 h / 20 °C

In water; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2011.07.043