ethyl 7-(4-(tert-butoxycarbonyl)-2-nitrophenoxy)-6,8-dichlorochroman-4-carboxylate

Base Information

Chemical Name:ethyl 7-(4-(tert-butoxycarbonyl)-2-nitrophenoxy)-6,8-dichlorochroman-4-carboxylate
CAS No.:1233696-44-0
Molecular Formula:C₂₃H₂₃Cl₂NO₈
Molecular Weight:512.344
Hs Code.:

Synonyms:ethyl 7-(4-(tert-butoxycarbonyl)-2-nitrophenoxy)-6,8-dichlorochroman-4-carboxylate

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Chemical Property of ethyl 7-(4-(tert-butoxycarbonyl)-2-nitrophenoxy)-6,8-dichlorochroman-4-carboxylate

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Technology Process of ethyl 7-(4-(tert-butoxycarbonyl)-2-nitrophenoxy)-6,8-dichlorochroman-4-carboxylate

There total 11 articles about ethyl 7-(4-(tert-butoxycarbonyl)-2-nitrophenoxy)-6,8-dichlorochroman-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.3%

: 579514-75-3
tert-butyl 4-fluoro-3-nitrobenzoate

: 1202890-12-7
ethyl 6,8-dichloro-7-hydroxychroman-4-carboxylate

: 1233696-44-0
ethyl 7-(4-(tert-butoxycarbonyl)-2-nitrophenoxy)-6,8-dichlorochroman-4-carboxylate

Guidance literature:: tert-butyl 4-fluoro-3-nitrobenzoate; ethyl 6,8-dichloro-7-hydroxychroman-4-carboxylate; With potassium carbonate; In 1-methyl-pyrrolidin-2-one; at 80 ℃; Inert atmosphere;

With hydrogenchloride; In 1-methyl-pyrrolidin-2-one; water; pH=1 - 2;

Reference yield:

: 74277-66-0
6-chloro-7-hydroxychroman-4-one

: 1233696-44-0
ethyl 7-(4-(tert-butoxycarbonyl)-2-nitrophenoxy)-6,8-dichlorochroman-4-carboxylate

Guidance literature:: Multi-step reaction with 7 steps

1.1: iodine / dichloromethane / 10 - 20 °C / Inert atmosphere; Industry scale

1.2: 20 °C / Industry scale

2.1: hydrogenchloride; tin(II) chloride dihdyrate; water / acetic acid / 20 - 85 °C / Industry scale

3.1: sulfuric acid / 16.16 h / 20 °C / Reflux; Industry scale

4.1: N,N-dimethylglycine hydrochoride; caesium carbonate; copper(l) chloride / 1,4-dioxane / 20 h / 95 - 97 °C / Inert atmosphere

5.1: hydrogenchloride / ethyl acetate / 16 h / 20 °C

6.1: diisobutylamine; sulfuryl dichloride / toluene / 1 h / 70 °C

7.1: potassium carbonate / 1-methyl-pyrrolidin-2-one / 4 h / 80 °C / Inert atmosphere

7.2: pH 2

With hydrogenchloride; diisobutylamine; sulfuryl dichloride; tin(II) chloride dihdyrate; sulfuric acid; water; iodine; N,N-dimethylglycine hydrochoride; potassium carbonate; caesium carbonate; copper(l) chloride; In 1,4-dioxane; 1-methyl-pyrrolidin-2-one; dichloromethane; acetic acid; ethyl acetate; toluene;

Reference yield:

: 1202889-56-2
3-chloro-1-(5-chloro-2,4-dihydroxyphenyl)propan-1-one

: 1233696-44-0
ethyl 7-(4-(tert-butoxycarbonyl)-2-nitrophenoxy)-6,8-dichlorochroman-4-carboxylate

Guidance literature:: Multi-step reaction with 8 steps

1.1: sodium hydroxide / water / 10 - 20 °C / Industry scale

1.2: 1 h / 5 - 20 °C

2.1: iodine / dichloromethane / 10 - 20 °C / Inert atmosphere; Industry scale

2.2: 20 °C / Industry scale

3.1: hydrogenchloride; tin(II) chloride dihdyrate; water / acetic acid / 18 h / 100 °C / Industry scale

3.2: 1 h / 20 °C / Industry scale

4.1: sodium hydroxide / water / Industry scale

4.2: pH 2 - 3 / Industry scale

4.3: 16 h / Reflux

5.1: N,N-dimethylglycine hydrochoride; caesium carbonate; copper(l) chloride / 1,4-dioxane / 20 h / 95 - 97 °C / Inert atmosphere

6.1: hydrogenchloride / ethyl acetate / 16 h / 20 °C

7.1: diisobutylamine; sulfuryl dichloride / toluene / 1 h / 70 °C

8.1: potassium carbonate / 1-methyl-pyrrolidin-2-one / 4 h / 80 °C / Inert atmosphere

8.2: pH 2

With hydrogenchloride; diisobutylamine; sulfuryl dichloride; tin(II) chloride dihdyrate; water; iodine; N,N-dimethylglycine hydrochoride; potassium carbonate; caesium carbonate; copper(l) chloride; sodium hydroxide; In 1,4-dioxane; 1-methyl-pyrrolidin-2-one; dichloromethane; water; acetic acid; ethyl acetate; toluene;