Technology Process of 2-amino-N5-<4-(L-glutamocarbonyl)benzyl>-5,6,7,8-tetrahydro-1H-imidazo<4,5-g>quinoline
There total 13 articles about 2-amino-N5-<4-(L-glutamocarbonyl)benzyl>-5,6,7,8-tetrahydro-1H-imidazo<4,5-g>quinoline which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
sodium hydroxide;
In
2-ethoxy-ethanol;
at 23 ℃;
for 1.5h;
DOI:10.1021/jm00083a007
- Guidance literature:
-
Multi-step reaction with 10 steps
1: 77 percent / CH2Cl2 / 0.17 h / 25 °C
2: 85 percent / H2 / PtO2 / acetic acid / 1.5 h / 1551.4 Torr
3: 98percent H2SO4, 70percent HNO3 / -10 °C
4: 88 percent / diisopropylethylamine / dimethylformamide / 5 h / 70 °C
5: 3 N aq. HCl / 5.5 h / 60 °C
6: 3 N aq. HCl / 5.5 h / 60 °C
7: 65 percent / triethylamine, 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride (EDC) / dimethylformamide / 12 h / Ambient temperature
8: Zn / acetic acid / 0.05 h / 23 °C
9: acetonitrile; methanol / 2 h / 70 °C
10: 73 percent / 1 N NaOH / 2-ethoxy-ethanol / 1.5 h / 23 °C
With
hydrogenchloride; sodium hydroxide; sulfuric acid; hydrogen; nitric acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; zinc;
platinum(IV) oxide;
In
methanol; 2-ethoxy-ethanol; dichloromethane; acetic acid; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm00083a007
- Guidance literature:
-
Multi-step reaction with 9 steps
1: 85 percent / H2 / PtO2 / acetic acid / 1.5 h / 1551.4 Torr
2: 98percent H2SO4, 70percent HNO3 / -10 °C
3: 88 percent / diisopropylethylamine / dimethylformamide / 5 h / 70 °C
4: 3 N aq. HCl / 5.5 h / 60 °C
5: 3 N aq. HCl / 5.5 h / 60 °C
6: 65 percent / triethylamine, 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride (EDC) / dimethylformamide / 12 h / Ambient temperature
7: Zn / acetic acid / 0.05 h / 23 °C
8: acetonitrile; methanol / 2 h / 70 °C
9: 73 percent / 1 N NaOH / 2-ethoxy-ethanol / 1.5 h / 23 °C
With
hydrogenchloride; sodium hydroxide; sulfuric acid; hydrogen; nitric acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; zinc;
platinum(IV) oxide;
In
methanol; 2-ethoxy-ethanol; acetic acid; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm00083a007
