3-<2,4-bis(methoxymethoxy)phenyl>-4-(4-methoxymethoxybenzyl)dihydro-tetronic acid

Base Information

• Chemical Name: 3-<2,4-bis(methoxymethoxy)phenyl>-4-(4-methoxymethoxybenzyl)dihydro-tetronic acid
• CAS No.: 130970-98-8
• Molecular Formula: C₂₃H₂₈O₉
• Molecular Weight: 448.47
• Mol file: 130970-98-8.mol

Synonyms:3-<2,4-bis(methoxymethoxy)phenyl>-4-(4-methoxymethoxybenzyl)dihydro-tetronic acid

Chemical Property of 3-<2,4-bis(methoxymethoxy)phenyl>-4-(4-methoxymethoxybenzyl)dihydro-tetronic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-<2,4-bis(methoxymethoxy)phenyl>-4-(4-methoxymethoxybenzyl)dihydro-tetronic acid

There total 6 articles about 3-<2,4-bis(methoxymethoxy)phenyl>-4-(4-methoxymethoxybenzyl)dihydro-tetronic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

α-acetoxy-2',4,4'-tris(methoxymethoxy)dihydrochalcone (130970-96-6) → 3-<2,4-bis(methoxymethoxy)phenyl>-4-(4-methoxymethoxybenzyl)but-2-en-4-olide (130970-97-7) + 3-<2,4-bis(methoxymethoxy)phenyl>-4-(4-methoxymethoxybenzyl)dihydro-tetronic acid (130970-98-8)

Guidance literature:

With lithium diisopropyl amide; In tetrahydrofuran; for 4h; Ambient temperature;

Reference yield:

(+/-)-2,3-trans-2,3-epoxy-1-2,4-bis(methoxymethoxy)phenyl-3-4'-methoxymethoxyphenylpropanone (6515-16-8) → 3-<2,4-bis(methoxymethoxy)phenyl>-4-(4-methoxymethoxybenzyl)dihydro-tetronic acid (130970-98-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 88 percent / H₂ / Pd-BaSO₄ / ethanol / 1.5 h

2: 95 percent / pyridine

3: 41 percent / LDA / tetrahydrofuran / 4 h / Ambient temperature

With pyridine; hydrogen; lithium diisopropyl amide; palladium on barium sulfate; In tetrahydrofuran; ethanol;

Reference yield:

4-methoxymethoxy-benzaldehyde (6515-21-5) → 3-<2,4-bis(methoxymethoxy)phenyl>-4-(4-methoxymethoxybenzyl)dihydro-tetronic acid (130970-98-8)

Guidance literature:

Multi-step reaction with 5 steps

1: 1) LDA / 1) THF, RT, 15min, 2) THF, 14h

2: 6percent H₂O₂, 1M NaOH / methanol / 2 h

3: 88 percent / H₂ / Pd-BaSO₄ / ethanol / 1.5 h

4: 95 percent / pyridine

5: 41 percent / LDA / tetrahydrofuran / 4 h / Ambient temperature

With pyridine; sodium hydroxide; hydrogen; dihydrogen peroxide; lithium diisopropyl amide; palladium on barium sulfate; In tetrahydrofuran; methanol; ethanol;

upstream raw materials:

α-acetoxy-2',4,4'-tris(methoxymethoxy)dihydrochalcone

(+/-)-2,3-trans-2,3-epoxy-1-2,4-bis(methoxymethoxy)phenyl-3-4'-methoxymethoxyphenylpropanone

4-methoxymethoxy-benzaldehyde

2',4'-bis(methoxymethoxy)acetophenone

Downstream raw materials:

3-(2,4-dihydroxyphenyl)-4-(4-hydroxyphenyl)but-2-en-4-olide

3-(4-acetoxyphenyl)-4-(2,4-diacetoxyphenyl)but-2-en-4-olide