(R)-N-(7-(1-((4'-chloro-biphenyl-2-yl)methyl)piperidin-4-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4-yl)-4-((4-(dimethylamino)-1-(phenylthio)butan-2-yl)amino)-3-((trifluoromethyl)sulfonyl)benzenesulfonamide

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Chemical Name:(R)-N-(7-(1-((4'-chloro-biphenyl-2-yl)methyl)piperidin-4-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4-yl)-4-((4-(dimethylamino)-1-(phenylthio)butan-2-yl)amino)-3-((trifluoromethyl)sulfonyl)benzenesulfonamide
CAS No.:1274802-50-4
Molecular Formula:C₄₄H₄₉ClF₃N₇O₄S₃
Molecular Weight:928.564
Hs Code.:

(R)-N-(7-(1-((4'-chloro-biphenyl-2-yl)methyl)piperidin-4-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4-yl)-4-((4-(dimethylamino)-1-(phenylthio)butan-2-yl)amino)-3-((trifluoromethyl)sulfonyl)benzenesulfonamide

Synonyms:(R)-N-(7-(1-((4'-chloro-biphenyl-2-yl)methyl)piperidin-4-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4-yl)-4-((4-(dimethylamino)-1-(phenylthio)butan-2-yl)amino)-3-((trifluoromethyl)sulfonyl)benzenesulfonamide

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Chemical Property of (R)-N-(7-(1-((4'-chloro-biphenyl-2-yl)methyl)piperidin-4-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4-yl)-4-((4-(dimethylamino)-1-(phenylthio)butan-2-yl)amino)-3-((trifluoromethyl)sulfonyl)benzenesulfonamide

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Technology Process of (R)-N-(7-(1-((4'-chloro-biphenyl-2-yl)methyl)piperidin-4-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4-yl)-4-((4-(dimethylamino)-1-(phenylthio)butan-2-yl)amino)-3-((trifluoromethyl)sulfonyl)benzenesulfonamide

There total 11 articles about (R)-N-(7-(1-((4'-chloro-biphenyl-2-yl)methyl)piperidin-4-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4-yl)-4-((4-(dimethylamino)-1-(phenylthio)butan-2-yl)amino)-3-((trifluoromethyl)sulfonyl)benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 19.0%

: 1274804-88-4
1-(4'-chloro-biphenyl-2-ylmethyl)-piperidin-4-one

: 1274804-71-5
4-((R)-3-dimethylamino-1-phenylsulfanylmethyl-propylamino)-N-(5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidin-4-yl)-3-(trifluoromethanesulfonyl)benzenesulfonamide

: 1274802-50-4
(R)-N-(7-(1-((4'-chloro-biphenyl-2-yl)methyl)piperidin-4-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4-yl)-4-((4-(dimethylamino)-1-(phenylthio)butan-2-yl)amino)-3-((trifluoromethyl)sulfonyl)benzenesulfonamide

Guidance literature:: With sodium tris(acetoxy)borohydride; acetic acid; In 1,2-dichloro-ethane; at 45 ℃; for 12h; Inert atmosphere; Molecular sieve;
DOI:10.1021/ml300321d

Reference yield:

: 39514-19-7
ethyl 1-benzyl-3-oxo-4-piperidinecarboxylate

: 1274802-50-4
(R)-N-(7-(1-((4'-chloro-biphenyl-2-yl)methyl)piperidin-4-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4-yl)-4-((4-(dimethylamino)-1-(phenylthio)butan-2-yl)amino)-3-((trifluoromethyl)sulfonyl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 6 steps

1: triethylamine; 10 wt% Pd(OH)2 on carbon; hydrogen / ethanol / Inert atmosphere

2: sodium; ethanol / 20 - 75 °C / Inert atmosphere

3: tetrachloromethane; triphenylphosphine / 1,2-dichloro-ethane / 2.5 h / 70 °C / Inert atmosphere

4: caesium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; DavePhos / 1,4-dioxane / 0.5 h / 180 °C / Inert atmosphere

5: trifluoroacetic acid / dichloromethane / 1 h / 0 °C / Inert atmosphere

6: acetic acid; sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 12 h / 45 °C / Inert atmosphere; Molecular sieve

With tetrachloromethane; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; ethanol; 10 wt% Pd(OH)2 on carbon; hydrogen; sodium; sodium tris(acetoxy)borohydride; caesium carbonate; acetic acid; triethylamine; triphenylphosphine; trifluoroacetic acid; DavePhos; In 1,4-dioxane; ethanol; dichloromethane; 1,2-dichloro-ethane;
DOI:10.1021/ml300321d

Reference yield:

: 70637-75-1
ethyl 3-oxopiperidine-4-carboxylate

: 1274802-50-4
(R)-N-(7-(1-((4'-chloro-biphenyl-2-yl)methyl)piperidin-4-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4-yl)-4-((4-(dimethylamino)-1-(phenylthio)butan-2-yl)amino)-3-((trifluoromethyl)sulfonyl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 6 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane / 16 h / 20 °C / Inert atmosphere

2: sodium; ethanol / 20 - 75 °C / Inert atmosphere

3: tetrachloromethane; triphenylphosphine / 1,2-dichloro-ethane / 2.5 h / 70 °C / Inert atmosphere

4: caesium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; DavePhos / 1,4-dioxane / 0.5 h / 180 °C / Inert atmosphere

5: trifluoroacetic acid / dichloromethane / 1 h / 0 °C / Inert atmosphere

6: acetic acid; sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 12 h / 45 °C / Inert atmosphere; Molecular sieve

With tetrachloromethane; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; ethanol; sodium; sodium tris(acetoxy)borohydride; caesium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; triphenylphosphine; trifluoroacetic acid; DavePhos; In 1,4-dioxane; dichloromethane; 1,2-dichloro-ethane;
DOI:10.1021/ml300321d