4-((R)-3-dimethylamino-1-phenylsulfanylmethyl-propylamino)-N-(5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidin-4-yl)-3-(trifluoromethanesulfonyl)benzenesulfonamide

Base Information

Chemical Name:4-((R)-3-dimethylamino-1-phenylsulfanylmethyl-propylamino)-N-(5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidin-4-yl)-3-(trifluoromethanesulfonyl)benzenesulfonamide
CAS No.:1274804-71-5
Molecular Formula:C₂₆H₃₁F₃N₆O₄S₃
Molecular Weight:644.763
Hs Code.:

4-((R)-3-dimethylamino-1-phenylsulfanylmethyl-propylamino)-N-(5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidin-4-yl)-3-(trifluoromethanesulfonyl)benzenesulfonamide

Synonyms:4-((R)-3-dimethylamino-1-phenylsulfanylmethyl-propylamino)-N-(5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidin-4-yl)-3-(trifluoromethanesulfonyl)benzenesulfonamide

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Chemical Property of 4-((R)-3-dimethylamino-1-phenylsulfanylmethyl-propylamino)-N-(5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidin-4-yl)-3-(trifluoromethanesulfonyl)benzenesulfonamide

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Technology Process of 4-((R)-3-dimethylamino-1-phenylsulfanylmethyl-propylamino)-N-(5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidin-4-yl)-3-(trifluoromethanesulfonyl)benzenesulfonamide

There total 7 articles about 4-((R)-3-dimethylamino-1-phenylsulfanylmethyl-propylamino)-N-(5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidin-4-yl)-3-(trifluoromethanesulfonyl)benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 1274804-57-7
(R)-tert-butyl 4-(4-(4-(dimethylamino)-1-(phenylthio)butan-2-ylamino)-3-(trifluoromethylsulfonyl)phenylsulfonamido)-5,6-dihydropyrido[3,4-d]pyrimidine-7(8H)-carboxylate

: 1274804-71-5
4-((R)-3-dimethylamino-1-phenylsulfanylmethyl-propylamino)-N-(5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidin-4-yl)-3-(trifluoromethanesulfonyl)benzenesulfonamide

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 0 ℃; for 1h; Inert atmosphere;
DOI:10.1021/ml300321d

Reference yield:

: 39514-19-7
ethyl 1-benzyl-3-oxo-4-piperidinecarboxylate

: 1274804-71-5
4-((R)-3-dimethylamino-1-phenylsulfanylmethyl-propylamino)-N-(5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidin-4-yl)-3-(trifluoromethanesulfonyl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1: triethylamine; 10 wt% Pd(OH)2 on carbon; hydrogen / ethanol / Inert atmosphere

2: sodium; ethanol / 20 - 75 °C / Inert atmosphere

3: tetrachloromethane; triphenylphosphine / 1,2-dichloro-ethane / 2.5 h / 70 °C / Inert atmosphere

4: caesium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; DavePhos / 1,4-dioxane / 0.5 h / 180 °C / Inert atmosphere

5: trifluoroacetic acid / dichloromethane / 1 h / 0 °C / Inert atmosphere

With tetrachloromethane; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; ethanol; 10 wt% Pd(OH)2 on carbon; hydrogen; sodium; caesium carbonate; triethylamine; triphenylphosphine; trifluoroacetic acid; DavePhos; In 1,4-dioxane; ethanol; dichloromethane; 1,2-dichloro-ethane;
DOI:10.1021/ml300321d

Reference yield:

: 70637-75-1
ethyl 3-oxopiperidine-4-carboxylate

: 1274804-71-5
4-((R)-3-dimethylamino-1-phenylsulfanylmethyl-propylamino)-N-(5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidin-4-yl)-3-(trifluoromethanesulfonyl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane / 16 h / 20 °C / Inert atmosphere

2: sodium; ethanol / 20 - 75 °C / Inert atmosphere

3: tetrachloromethane; triphenylphosphine / 1,2-dichloro-ethane / 2.5 h / 70 °C / Inert atmosphere

4: caesium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; DavePhos / 1,4-dioxane / 0.5 h / 180 °C / Inert atmosphere

5: trifluoroacetic acid / dichloromethane / 1 h / 0 °C / Inert atmosphere

With tetrachloromethane; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; ethanol; sodium; caesium carbonate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; trifluoroacetic acid; DavePhos; In 1,4-dioxane; dichloromethane; 1,2-dichloro-ethane;
DOI:10.1021/ml300321d