rac-tert-butyl [2-(2,4-difluorophenyl)-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)ethyl]carbamate

Base Information

Chemical Name:rac-tert-butyl [2-(2,4-difluorophenyl)-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)ethyl]carbamate
CAS No.:1609344-58-2
Molecular Formula:C₂₁H₂₀F₂N₂O₄
Molecular Weight:402.398
Hs Code.:

Synonyms:rac-tert-butyl [2-(2,4-difluorophenyl)-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)ethyl]carbamate

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Chemical Property of rac-tert-butyl [2-(2,4-difluorophenyl)-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)ethyl]carbamate

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Technology Process of rac-tert-butyl [2-(2,4-difluorophenyl)-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)ethyl]carbamate

There total 2 articles about rac-tert-butyl [2-(2,4-difluorophenyl)-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)ethyl]carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 24.0%

: 777906-01-1
rac-3-(2,4-difluorophenyl)-3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)propanoic acid

: 75-65-0
tert-butyl alcohol

: 1609344-58-2
rac-tert-butyl [2-(2,4-difluorophenyl)-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)ethyl]carbamate

Guidance literature:: rac-3-(2,4-difluorophenyl)-3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)propanoic acid; With diphenyl phosphoryl azide; triethylamine; In toluene; for 3.5h; Inert atmosphere; Cooling;

tert-butyl alcohol; In toluene; Reflux;

Reference yield:

: 85-44-9
phthalic anhydride

: 412925-23-6
rac-3-amino-3-(2,4-difluorophenyl)propanoic acid

: 1609344-58-2
rac-tert-butyl [2-(2,4-difluorophenyl)-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)ethyl]carbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: N,N-dimethyl-formamide / 135 °C

2.1: triethylamine; diphenyl phosphoryl azide / toluene / 3.5 h / Inert atmosphere; Cooling

2.2: Reflux

With diphenyl phosphoryl azide; triethylamine; In N,N-dimethyl-formamide; toluene;