5-((1S,4S)-2,5-diazabicyclo[2.2.1]heptan-2-yl)-N-(2-(isopropylamino)-2-oxoethyl)-2-nitrobenzamide

Base Information

Chemical Name:5-((1S,4S)-2,5-diazabicyclo[2.2.1]heptan-2-yl)-N-(2-(isopropylamino)-2-oxoethyl)-2-nitrobenzamide
CAS No.:1290634-18-2
Molecular Formula:C₁₇H₂₃N₅O₄
Molecular Weight:361.401
Hs Code.:

Synonyms:5-((1S,4S)-2,5-diazabicyclo[2.2.1]heptan-2-yl)-N-(2-(isopropylamino)-2-oxoethyl)-2-nitrobenzamide

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Chemical Property of 5-((1S,4S)-2,5-diazabicyclo[2.2.1]heptan-2-yl)-N-(2-(isopropylamino)-2-oxoethyl)-2-nitrobenzamide

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Technology Process of 5-((1S,4S)-2,5-diazabicyclo[2.2.1]heptan-2-yl)-N-(2-(isopropylamino)-2-oxoethyl)-2-nitrobenzamide

There total 4 articles about 5-((1S,4S)-2,5-diazabicyclo[2.2.1]heptan-2-yl)-N-(2-(isopropylamino)-2-oxoethyl)-2-nitrobenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1290633-87-2
(1S,4S)-tert-butyl 5-(3-(2-(isopropylamino)-2-oxoethylcarbamoyl)-4-nitrophenyl)-2,5-diazabicyclo[2.2.1]heptane-2-carboxylate

: 1290634-18-2
5-((1S,4S)-2,5-diazabicyclo[2.2.1]heptan-2-yl)-N-(2-(isopropylamino)-2-oxoethyl)-2-nitrobenzamide

Guidance literature:: With trifluoroacetic acid; In dichloromethane;

Reference yield:

: 320-98-9
5-fluoro-2-nitrobenzoic acid

: 1290634-18-2
5-((1S,4S)-2,5-diazabicyclo[2.2.1]heptan-2-yl)-N-(2-(isopropylamino)-2-oxoethyl)-2-nitrobenzamide

Guidance literature:: Multi-step reaction with 4 steps

1: thionyl chloride / 2.5 h / Reflux

2: N-ethyl-N,N-diisopropylamine / dichloromethane / Cooling with ice

3: potassium carbonate / acetonitrile / 6 h / 90 °C

4: trifluoroacetic acid / dichloromethane

With thionyl chloride; potassium carbonate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane; acetonitrile;

Reference yield:

: 394-02-5
5-fluoro-2-nitrobenzoyl chloride

: 1290634-18-2
5-((1S,4S)-2,5-diazabicyclo[2.2.1]heptan-2-yl)-N-(2-(isopropylamino)-2-oxoethyl)-2-nitrobenzamide

Guidance literature:: Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane / Cooling with ice

2: potassium carbonate / acetonitrile / 6 h / 90 °C

3: trifluoroacetic acid / dichloromethane

With potassium carbonate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane; acetonitrile;