O-(1,2-O-di-n-hexanoyl-sn-3-glyceryl) O-(D-2'-deoxy-2'-fluoro-3',4',5',6'-tetra-O-benzyl-scyllo-inositol) O-(2''-(-trimethylsilyl)ethyl) phosphate

Base Information

Chemical Name:O-(1,2-O-di-n-hexanoyl-sn-3-glyceryl) O-(D-2'-deoxy-2'-fluoro-3',4',5',6'-tetra-O-benzyl-scyllo-inositol) O-(2''-(-trimethylsilyl)ethyl) phosphate
CAS No.:160531-85-1
Molecular Formula:C₅₄H₇₄FO₁₂PSi
Molecular Weight:993.232
Hs Code.:

Synonyms:O-(1,2-O-di-n-hexanoyl-sn-3-glyceryl) O-(D-2'-deoxy-2'-fluoro-3',4',5',6'-tetra-O-benzyl-scyllo-inositol) O-(2''-(-trimethylsilyl)ethyl) phosphate

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Chemical Property of O-(1,2-O-di-n-hexanoyl-sn-3-glyceryl) O-(D-2'-deoxy-2'-fluoro-3',4',5',6'-tetra-O-benzyl-scyllo-inositol) O-(2''-(-trimethylsilyl)ethyl) phosphate

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Technology Process of O-(1,2-O-di-n-hexanoyl-sn-3-glyceryl) O-(D-2'-deoxy-2'-fluoro-3',4',5',6'-tetra-O-benzyl-scyllo-inositol) O-(2''-(-trimethylsilyl)ethyl) phosphate

There total 9 articles about O-(1,2-O-di-n-hexanoyl-sn-3-glyceryl) O-(D-2'-deoxy-2'-fluoro-3',4',5',6'-tetra-O-benzyl-scyllo-inositol) O-(2''-(-trimethylsilyl)ethyl) phosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 108609-67-2
benzyl (2S)-2,3-bis(hexanoyloxy)-1-propyl ether

: 160531-85-1
O-(1,2-O-di-n-hexanoyl-sn-3-glyceryl) O-(D-2'-deoxy-2'-fluoro-3',4',5',6'-tetra-O-benzyl-scyllo-inositol) O-(2''-(-trimethylsilyl)ethyl) phosphate

Guidance literature:: Multi-step reaction with 3 steps

1: 87 percent / H₂ / 10percent Pd/C / ethanol; acetic acid / Ambient temperature

2: N,N-diisopropylethylamine / tetrahydrofuran / -78 °C / -78 deg C, 2 h; r.t., 1 h

3: tert-butyl hydroperoxide / CH₂Cl₂ / 1 h / 0 °C

With tert.-butylhydroperoxide; hydrogen; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; acetic acid;
DOI:10.1021/jo00096a023

Reference yield:

: 142-62-1
hexanoic acid

: 160531-85-1
O-(1,2-O-di-n-hexanoyl-sn-3-glyceryl) O-(D-2'-deoxy-2'-fluoro-3',4',5',6'-tetra-O-benzyl-scyllo-inositol) O-(2''-(-trimethylsilyl)ethyl) phosphate

Guidance literature:: Multi-step reaction with 4 steps

1: 86 percent / DCC, DMAP / CH₂Cl₂ / 10 h / Ambient temperature

2: 87 percent / H₂ / 10percent Pd/C / ethanol; acetic acid / Ambient temperature

3: N,N-diisopropylethylamine / tetrahydrofuran / -78 °C / -78 deg C, 2 h; r.t., 1 h

4: tert-butyl hydroperoxide / CH₂Cl₂ / 1 h / 0 °C

With tert.-butylhydroperoxide; dmap; hydrogen; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; acetic acid;
DOI:10.1021/jo00096a023

Reference yield:

: 30403-47-5,75685-80-2
1,2-dihexanoyl-sn-glycerol

: 160531-85-1
O-(1,2-O-di-n-hexanoyl-sn-3-glyceryl) O-(D-2'-deoxy-2'-fluoro-3',4',5',6'-tetra-O-benzyl-scyllo-inositol) O-(2''-(-trimethylsilyl)ethyl) phosphate

Guidance literature:: Multi-step reaction with 2 steps

1: N,N-diisopropylethylamine / tetrahydrofuran / -78 °C / -78 deg C, 2 h; r.t., 1 h

2: tert-butyl hydroperoxide / CH₂Cl₂ / 1 h / 0 °C

With tert.-butylhydroperoxide; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jo00096a023