3-(1-Benzyl-pyrrolidin-3-ylamino)-4-(2,2-dimethoxy-ethyl)-benzoic acid methyl ester

Base Information

• Chemical Name: 3-(1-Benzyl-pyrrolidin-3-ylamino)-4-(2,2-dimethoxy-ethyl)-benzoic acid methyl ester
• CAS No.: 1071216-81-3
• Molecular Formula: C₂₃H₃₀N₂O₄
• Molecular Weight: 398.502
• Mol file: 1071216-81-3.mol

Synonyms:3-(1-Benzyl-pyrrolidin-3-ylamino)-4-(2,2-dimethoxy-ethyl)-benzoic acid methyl ester

Chemical Property of 3-(1-Benzyl-pyrrolidin-3-ylamino)-4-(2,2-dimethoxy-ethyl)-benzoic acid methyl ester

Chemical Property:

Purity/Quality:

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Technology Process of 3-(1-Benzyl-pyrrolidin-3-ylamino)-4-(2,2-dimethoxy-ethyl)-benzoic acid methyl ester

There total 3 articles about 3-(1-Benzyl-pyrrolidin-3-ylamino)-4-(2,2-dimethoxy-ethyl)-benzoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-methyl-3-nitrobenzoic acid (96-98-0) → 3-(1-Benzyl-pyrrolidin-3-ylamino)-4-(2,2-dimethoxy-ethyl)-benzoic acid methyl ester (1071216-81-3)

Guidance literature:

Multi-step reaction with 4 steps

1: 81 percent / dimethylformamide / 18 h / 140 °C

2: ClSiMe₃ / 18 h / Heating

3: 82 percent / hydrogen / 10percent Pd/C / methanol / 2585.7 Torr

4: 1) Na₂SO₄, 2) NaBH(OAc)3 / 1) AcOH, 2) AcOH

With chloro-trimethyl-silane; hydrogen; sodium tris(acetoxy)borohydride; sodium sulfate; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide;

DOI:10.1016/0040-4039(96)01311-1

Reference yield:

2,2-dimethoxy-1-(4-methoxycarbonyl-2-nitrophenyl)ethane (146667-95-0) → 3-(1-Benzyl-pyrrolidin-3-ylamino)-4-(2,2-dimethoxy-ethyl)-benzoic acid methyl ester (1071216-81-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 82 percent / hydrogen / 10percent Pd/C / methanol / 2585.7 Torr

2: 1) Na₂SO₄, 2) NaBH(OAc)3 / 1) AcOH, 2) AcOH

With hydrogen; sodium tris(acetoxy)borohydride; sodium sulfate; palladium on activated charcoal; In methanol;

DOI:10.1016/0040-4039(96)01311-1

Reference yield:

N-benzyl-3-pyrrolidinone (775-16-6) + 2-amino-4-carbomethoxy-phenylacetaldehyde dimethylacetal (167478-76-4) → 3-(1-Benzyl-pyrrolidin-3-ylamino)-4-(2,2-dimethoxy-ethyl)-benzoic acid methyl ester (1071216-81-3)

Guidance literature:

With sodium tris(acetoxy)borohydride; sodium sulfate; Multistep reaction; 1) AcOH, 2) AcOH;

DOI:10.1016/0040-4039(96)01311-1

upstream raw materials:

N-benzyl-3-pyrrolidinone

2-amino-4-carbomethoxy-phenylacetaldehyde dimethylacetal

4-methyl-3-nitrobenzoic acid

2,2-dimethoxy-1-(4-methoxycarbonyl-2-nitrophenyl)ethane