trichloroethyl 2β-(chloromethyl)-2α-methyl-6β-(phenoxyacetamido)-penam-3α-carboxylate

Base Information

• Chemical Name: trichloroethyl 2β-(chloromethyl)-2α-methyl-6β-(phenoxyacetamido)-penam-3α-carboxylate
• CAS No.: 51415-42-0
• Molecular Formula: C₁₈H₁₈Cl₄N₂O₅S
• Molecular Weight: 516.229
• Mol file: 51415-42-0.mol

Synonyms:trichloroethyl 2β-(chloromethyl)-2α-methyl-6β-(phenoxyacetamido)-penam-3α-carboxylate

Chemical Property of trichloroethyl 2β-(chloromethyl)-2α-methyl-6β-(phenoxyacetamido)-penam-3α-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of trichloroethyl 2β-(chloromethyl)-2α-methyl-6β-(phenoxyacetamido)-penam-3α-carboxylate

There total 3 articles about trichloroethyl 2β-(chloromethyl)-2α-methyl-6β-(phenoxyacetamido)-penam-3α-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-3,3-Dimethyl-4,7-dioxo-6-(2-phenoxy-acetylamino)-4λ4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid 2,2,2-trichloro-ethyl ester (19474-21-6,27250-42-6,30199-55-4,90026-86-1) → (2S,3S)-3-Chloromethyl-3-methyl-7-oxo-6-(2-phenoxy-acetylamino)-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid 2,2,2-trichloro-ethyl ester (51415-42-0,52842-52-1,75645-44-2,104641-33-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 95 percent / dioxane / 12 h / Heating

2: cupric chloride

With copper dichloride; In 1,4-dioxane;

DOI:10.1016/S0040-4039(01)80900-X

Reference yield:

C40H38Cl6N6O10S4 (104574-04-1) → (2S,3S)-3-Chloromethyl-3-methyl-7-oxo-6-(2-phenoxy-acetylamino)-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid 2,2,2-trichloro-ethyl ester (51415-42-0,52842-52-1,75645-44-2,104641-33-0)

Guidance literature:

With copper dichloride; Yield given;

DOI:10.1016/S0040-4039(01)80900-X

Reference yield:

C38H36Cl6N6O10S5 (104574-02-9) → (2S,3S)-3-Chloromethyl-3-methyl-7-oxo-6-(2-phenoxy-acetylamino)-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid 2,2,2-trichloro-ethyl ester (51415-42-0,52842-52-1,75645-44-2,104641-33-0)

Guidance literature:

With copper dichloride; Yield given;

DOI:10.1016/S0040-4039(01)80900-X

upstream raw materials:

C₄₀H₃₈Cl₆N₆O₁₀S₄

C₃₈H₃₆Cl₆N₆O₁₀S₅

(S)-3,3-Dimethyl-4,7-dioxo-6-(2-phenoxy-acetylamino)-4λ⁴-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid 2,2,2-trichloro-ethyl ester

Downstream raw materials:

trichloroethyl 2α-<(1-methyl-1,2,3,4-tetrazol-5-yl)thiomethyl>-2β-methyl-6β-(phenoxyacetamido)penam-3α-carboxylate

trichloroethyl 2α-<(2-methyl-1,3,4-thiadiazol-5-yl)thiomethyl>-2β-methyl-6β-(phenoxyacetamido)-penam-3α-carboxylate

trichloroethyl 2α-(chloromethyl)-2β-methyl-6β-(phenoxyacetamido)-penam-3α-carboxylate 1S-oxide

trichloroethyl 2β-(chloromethyl)-2α-methyl-6β-(phenoxyacetamido)-penam-3α-carboxylate 1R-oxide