(1S^*,2S^*)-1-acetoxy-2-methoxy-1-phenyl-2-(phenylthio)ethane

Base Information

• Chemical Name: (1S^*,2S^*)-1-acetoxy-2-methoxy-1-phenyl-2-(phenylthio)ethane
• CAS No.: 129756-71-4
• Molecular Formula: C₁₇H₁₈O₃S
• Molecular Weight: 302.394
• Mol file: 129756-71-4.mol

Synonyms:(1S^*,2S^*)-1-acetoxy-2-methoxy-1-phenyl-2-(phenylthio)ethane

Chemical Property of (1S^*,2S^*)-1-acetoxy-2-methoxy-1-phenyl-2-(phenylthio)ethane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1S^*,2S^*)-1-acetoxy-2-methoxy-1-phenyl-2-(phenylthio)ethane

There total 3 articles about (1S^*,2S^*)-1-acetoxy-2-methoxy-1-phenyl-2-(phenylthio)ethane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

acetic anhydride (108-24-7) + (1R,2R)-2-Methoxy-1-phenyl-2-phenylsulfanyl-ethanol (89036-90-8,134592-31-7,134592-32-8) → (1S*,2S*)-1-acetoxy-2-methoxy-1-phenyl-2-(phenylthio)ethane (129756-71-4)

Guidance literature:

With dmap; In pyridine;

DOI:10.1021/jo00312a016

Reference yield:

methoxymethyl phenyl sulfide (13865-50-4) → (1S*,2S*)-1-acetoxy-2-methoxy-1-phenyl-2-(phenylthio)ethane (129756-71-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 52 percent / BuLi / tetrahydrofuran; various solvent(s) / 3 h / -78 °C

2: 88 percent / 4-(Dimethylamino)-pyridine / pyridine

With dmap; n-butyllithium; In tetrahydrofuran; pyridine;

DOI:10.1021/jo00312a016

Reference yield:

benzaldehyde (100-52-7) → (1S*,2S*)-1-acetoxy-2-methoxy-1-phenyl-2-(phenylthio)ethane (129756-71-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 52 percent / BuLi / tetrahydrofuran; various solvent(s) / 3 h / -78 °C

2: 88 percent / 4-(Dimethylamino)-pyridine / pyridine

With dmap; n-butyllithium; In tetrahydrofuran; pyridine;

DOI:10.1021/jo00312a016

upstream raw materials:

acetic anhydride

(1R,2R)-2-Methoxy-1-phenyl-2-phenylsulfanyl-ethanol

methoxymethyl phenyl sulfide

benzaldehyde

Downstream raw materials:

C₁₈H₂₀OS

C₁₈H₂₀OS

(Z)-1-Acetoxy-2-methoxy-1-phenylethene