tert-butyl 3-(4-(5-(3-cyano-4-isopropyloxyphenyl)-1,2,4-oxadiazol-3-yl)-3-methylphenyl)propanoate

Base Information

Chemical Name:tert-butyl 3-(4-(5-(3-cyano-4-isopropyloxyphenyl)-1,2,4-oxadiazol-3-yl)-3-methylphenyl)propanoate
CAS No.:856166-10-4
Molecular Formula:C₂₆H₂₉N₃O₄
Molecular Weight:447.534
Hs Code.:

Synonyms:tert-butyl 3-(4-(5-(3-cyano-4-isopropyloxyphenyl)-1,2,4-oxadiazol-3-yl)-3-methylphenyl)propanoate

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Chemical Property of tert-butyl 3-(4-(5-(3-cyano-4-isopropyloxyphenyl)-1,2,4-oxadiazol-3-yl)-3-methylphenyl)propanoate

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Technology Process of tert-butyl 3-(4-(5-(3-cyano-4-isopropyloxyphenyl)-1,2,4-oxadiazol-3-yl)-3-methylphenyl)propanoate

There total 6 articles about tert-butyl 3-(4-(5-(3-cyano-4-isopropyloxyphenyl)-1,2,4-oxadiazol-3-yl)-3-methylphenyl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 258273-31-3
3-cyano-4-isopropoxybenzoic acid

: 856165-68-9
N-hydroxy-2-methyl-4-(2-(tert-butoxycarbonyl)ethyl)benzamidine

: 856166-10-4
tert-butyl 3-(4-(5-(3-cyano-4-isopropyloxyphenyl)-1,2,4-oxadiazol-3-yl)-3-methylphenyl)propanoate

Guidance literature:: With N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In acetonitrile; at 20 - 120 ℃; for 18h;

Reference yield:

: 856165-69-0
tert-butyl 3-(3-methyl-4-cyanophenyl)acrylate

: 856166-10-4
tert-butyl 3-(4-(5-(3-cyano-4-isopropyloxyphenyl)-1,2,4-oxadiazol-3-yl)-3-methylphenyl)propanoate

Guidance literature:: Multi-step reaction with 3 steps

1: H₂ / Pd/C / methanol / 20 °C / 775.72 Torr

2: NH₂OH*HCl; NaHCO₃ / methanol / 60 °C

3: EDC / 1,2-dichloro-ethane / 14 h / 100 °C

With hydroxylamine hydrochloride; hydrogen; sodium hydrogencarbonate; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; palladium on activated charcoal; In methanol; 1,2-dichloro-ethane;
DOI:10.1016/j.bmcl.2006.04.084

Reference yield:

: 1663-39-4,25232-27-3
tert-Butyl acrylate

: 856166-10-4
tert-butyl 3-(4-(5-(3-cyano-4-isopropyloxyphenyl)-1,2,4-oxadiazol-3-yl)-3-methylphenyl)propanoate

Guidance literature:: Multi-step reaction with 4 steps

1: Pd[P(tBu)3]2; Cy₂NCH₃ / dioxane / 70 °C

2: H₂ / Pd/C / methanol / 20 °C / 775.72 Torr

3: NH₂OH*HCl; NaHCO₃ / methanol / 60 °C

4: EDC / 1,2-dichloro-ethane / 14 h / 100 °C

With bis(tri-tert-butylphosphine)palladium⁽⁰⁾; N-Methyldicyclohexylamine; hydroxylamine hydrochloride; hydrogen; sodium hydrogencarbonate; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; palladium on activated charcoal; In 1,4-dioxane; methanol; 1,2-dichloro-ethane;
DOI:10.1016/j.bmcl.2006.04.084