{(S)-1-[(2S,5R)-2-Isopropyl-5-methyl-cyclohex-(E)-ylidenemethyl]-2,2-dimethyl-propyl}-carbamic acid 9H-fluoren-9-ylmethyl ester

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Chemical Name:{(S)-1-[(2S,5R)-2-Isopropyl-5-methyl-cyclohex-(E)-ylidenemethyl]-2,2-dimethyl-propyl}-carbamic acid 9H-fluoren-9-ylmethyl ester
CAS No.:750594-70-8
Molecular Formula:C₃₁H₄₁NO₂
Molecular Weight:459.672
Hs Code.:

Synonyms:{(S)-1-[(2S,5R)-2-Isopropyl-5-methyl-cyclohex-(E)-ylidenemethyl]-2,2-dimethyl-propyl}-carbamic acid 9H-fluoren-9-ylmethyl ester

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Chemical Property of {(S)-1-[(2S,5R)-2-Isopropyl-5-methyl-cyclohex-(E)-ylidenemethyl]-2,2-dimethyl-propyl}-carbamic acid 9H-fluoren-9-ylmethyl ester

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Technology Process of {(S)-1-[(2S,5R)-2-Isopropyl-5-methyl-cyclohex-(E)-ylidenemethyl]-2,2-dimethyl-propyl}-carbamic acid 9H-fluoren-9-ylmethyl ester

There total 4 articles about {(S)-1-[(2S,5R)-2-Isopropyl-5-methyl-cyclohex-(E)-ylidenemethyl]-2,2-dimethyl-propyl}-carbamic acid 9H-fluoren-9-ylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 24324-17-2
9-Fluorenylmethanol

: 750594-59-3
(S)-2-[(2S,5R)-2-Isopropyl-5-methyl-cyclohex-(E)-ylidenemethyl]-3,3-dimethyl-butyric acid

: 750594-70-8
{(S)-1-[(2S,5R)-2-Isopropyl-5-methyl-cyclohex-(E)-ylidenemethyl]-2,2-dimethyl-propyl}-carbamic acid 9H-fluoren-9-ylmethyl ester

Guidance literature:: (S)-2-[(2S,5R)-2-Isopropyl-5-methyl-cyclohex-(E)-ylidenemethyl]-3,3-dimethyl-butyric acid; With diphenyl-phosphinic acid; triethylamine; In toluene; for 1h; Heating;

9-Fluorenylmethanol; In toluene; for 1h; Heating;
DOI:10.1021/ol048936q

Reference yield:

: 750594-48-0
(1R,2S,5R)-2-i-propyl-5-methyl-1-(3-t-butyldimethylsyloxy-1-propen-1-yl)cyclohexan-1-ol

: 750594-70-8
{(S)-1-[(2S,5R)-2-Isopropyl-5-methyl-cyclohex-(E)-ylidenemethyl]-2,2-dimethyl-propyl}-carbamic acid 9H-fluoren-9-ylmethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: n-BuLi / tetrahydrofuran; hexane / 1 h / -78 - 0 °C

1.2: tetrahydrofuran; hexane / 2 h / 0 - 20 °C

2.1: CuCN / tetrahydrofuran; pentane / 0.5 h / -78 °C

2.2: 1.09 g / tetrahydrofuran; pentane / 4 h / -78 - 20 °C

3.1: 100 percent / Jones reagent / acetone / 2 h / 0 °C

4.1: DPPA; Et₃N / toluene / 1 h / Heating

4.2: 72 percent / toluene / 1 h / Heating

With n-butyllithium; jones reagent; diphenyl-phosphinic acid; triethylamine; In tetrahydrofuran; hexane; acetone; toluene; pentane; 4.1: Curtius rearrangement;
DOI:10.1021/ol048936q

Reference yield:

: 750594-50-4
Carbonic acid (1R,2S,5R)-1-[(E)-3-(tert-butyl-dimethyl-silanyloxy)-propenyl]-2-isopropyl-5-methyl-cyclohexyl ester methyl ester

: 750594-70-8
{(S)-1-[(2S,5R)-2-Isopropyl-5-methyl-cyclohex-(E)-ylidenemethyl]-2,2-dimethyl-propyl}-carbamic acid 9H-fluoren-9-ylmethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: CuCN / tetrahydrofuran; pentane / 0.5 h / -78 °C

1.2: 1.09 g / tetrahydrofuran; pentane / 4 h / -78 - 20 °C

2.1: 100 percent / Jones reagent / acetone / 2 h / 0 °C

3.1: DPPA; Et₃N / toluene / 1 h / Heating

3.2: 72 percent / toluene / 1 h / Heating

With jones reagent; diphenyl-phosphinic acid; triethylamine; In tetrahydrofuran; acetone; toluene; pentane; 3.1: Curtius rearrangement;
DOI:10.1021/ol048936q