(S)-2-[(2S,5R)-2-Isopropyl-5-methyl-cyclohex-(E)-ylidenemethyl]-3,3-dimethyl-butyric acid

Base Information

Chemical Name:(S)-2-[(2S,5R)-2-Isopropyl-5-methyl-cyclohex-(E)-ylidenemethyl]-3,3-dimethyl-butyric acid
CAS No.:750594-59-3
Molecular Formula:C₁₇H₃₀O₂
Molecular Weight:266.424
Hs Code.:

Synonyms:(S)-2-[(2S,5R)-2-Isopropyl-5-methyl-cyclohex-(E)-ylidenemethyl]-3,3-dimethyl-butyric acid

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Chemical Property of (S)-2-[(2S,5R)-2-Isopropyl-5-methyl-cyclohex-(E)-ylidenemethyl]-3,3-dimethyl-butyric acid

Chemical Property:

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MSDS Files:: SDS file from LookChem

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Technology Process of (S)-2-[(2S,5R)-2-Isopropyl-5-methyl-cyclohex-(E)-ylidenemethyl]-3,3-dimethyl-butyric acid

There total 3 articles about (S)-2-[(2S,5R)-2-Isopropyl-5-methyl-cyclohex-(E)-ylidenemethyl]-3,3-dimethyl-butyric acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 750594-52-6
tert-Butyl-{(S)-2-[(2S,5R)-2-isopropyl-5-methyl-cyclohex-(E)-ylidenemethyl]-3,3-dimethyl-butoxy}-dimethyl-silane

: 750594-59-3
(S)-2-[(2S,5R)-2-Isopropyl-5-methyl-cyclohex-(E)-ylidenemethyl]-3,3-dimethyl-butyric acid

Guidance literature:: With jones reagent; In acetone; at 0 ℃; for 2h;
DOI:10.1021/ol048936q

Reference yield:

: 750594-48-0
(1R,2S,5R)-2-i-propyl-5-methyl-1-(3-t-butyldimethylsyloxy-1-propen-1-yl)cyclohexan-1-ol

: 750594-59-3
(S)-2-[(2S,5R)-2-Isopropyl-5-methyl-cyclohex-(E)-ylidenemethyl]-3,3-dimethyl-butyric acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-BuLi / tetrahydrofuran; hexane / 1 h / -78 - 0 °C

1.2: tetrahydrofuran; hexane / 2 h / 0 - 20 °C

2.1: CuCN / tetrahydrofuran; pentane / 0.5 h / -78 °C

2.2: 1.09 g / tetrahydrofuran; pentane / 4 h / -78 - 20 °C

3.1: 100 percent / Jones reagent / acetone / 2 h / 0 °C

With n-butyllithium; jones reagent; In tetrahydrofuran; hexane; acetone; pentane;
DOI:10.1021/ol048936q

Reference yield:

: 750594-50-4
Carbonic acid (1R,2S,5R)-1-[(E)-3-(tert-butyl-dimethyl-silanyloxy)-propenyl]-2-isopropyl-5-methyl-cyclohexyl ester methyl ester

: 750594-59-3
(S)-2-[(2S,5R)-2-Isopropyl-5-methyl-cyclohex-(E)-ylidenemethyl]-3,3-dimethyl-butyric acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: CuCN / tetrahydrofuran; pentane / 0.5 h / -78 °C

1.2: 1.09 g / tetrahydrofuran; pentane / 4 h / -78 - 20 °C

2.1: 100 percent / Jones reagent / acetone / 2 h / 0 °C

With jones reagent; In tetrahydrofuran; acetone; pentane;
DOI:10.1021/ol048936q