N⁶-benzoyl-5'-O-(4,4'-dimethoxytrityl)-8-[2-(imidazol-4-yl)ethylamino]-2'-deoxyadenosine

Base Information

• Chemical Name: N⁶-benzoyl-5'-O-(4,4'-dimethoxytrityl)-8-[2-(imidazol-4-yl)ethylamino]-2'-deoxyadenosine
• CAS No.: 151322-48-4
• Molecular Formula: C₄₃H₄₂N₈O₆
• Molecular Weight: 766.856
• Mol file: 151322-48-4.mol

Synonyms:N⁶-benzoyl-5'-O-(4,4'-dimethoxytrityl)-8-[2-(imidazol-4-yl)ethylamino]-2'-deoxyadenosine

Chemical Property of N⁶-benzoyl-5'-O-(4,4'-dimethoxytrityl)-8-[2-(imidazol-4-yl)ethylamino]-2'-deoxyadenosine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N⁶-benzoyl-5'-O-(4,4'-dimethoxytrityl)-8-[2-(imidazol-4-yl)ethylamino]-2'-deoxyadenosine

There total 6 articles about N⁶-benzoyl-5'-O-(4,4'-dimethoxytrityl)-8-[2-(imidazol-4-yl)ethylamino]-2'-deoxyadenosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

N-(9-{5-[bis(4-methoxyphenyl)phenylmethoxyphenyl]-4-hydroxytetrahydrofuran-2-yl}-8-bromo-9H-purin-6-yl)benzamide (129451-79-2) + histamine (51-45-6) → N6-benzoyl-5'-O-(4,4'-dimethoxytrityl)-8-[2-(imidazol-4-yl)ethylamino]-2'-deoxyadenosine (151322-48-4)

Guidance literature:

In ethanol; for 18h; Ambient temperature;

DOI:10.1016/S0040-4020(01)89916-6

Reference yield: 72.5%

histamine dihydrochloride (55-36-7,56-92-8,23758-34-1,78654-37-2) + N-(9-{5-[bis(4-methoxyphenyl)phenylmethoxyphenyl]-4-hydroxytetrahydrofuran-2-yl}-8-bromo-9H-purin-6-yl)benzamide (129451-79-2) → N6-benzoyl-5'-O-(4,4'-dimethoxytrityl)-8-[2-(imidazol-4-yl)ethylamino]-2'-deoxyadenosine (151322-48-4)

Guidance literature:

With triethylamine; In ethanol; at 80 ℃; for 3h;

DOI:10.1039/d0ra02226h

Reference yield:

4,4'-dimethoxytrityl chloride (40615-36-9) → N6-benzoyl-5'-O-(4,4'-dimethoxytrityl)-8-[2-(imidazol-4-yl)ethylamino]-2'-deoxyadenosine (151322-48-4)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine

2: 79 percent / ethanol / 18 h / Ambient temperature

With pyridine; In ethanol;

DOI:10.1016/S0040-4020(01)89916-6

upstream raw materials:

N-(9-{5-[bis(4-methoxyphenyl)phenylmethoxyphenyl]-4-hydroxytetrahydrofuran-2-yl}-8-bromo-9H-purin-6-yl)benzamide

histamine

4,4'-dimethoxytrityl chloride

benzoyl chloride

Downstream raw materials:

3'-O-acetyl-N⁶-benzoyl-8-(1-N-acetylhistamino)-2'-deoxyadenosine