129451-79-2

Upstream product

• 40615-36-9 4,4'-dimethoxytrityl chloride 
• 129451-78-1 N-[8-Bromo-9-((2R,4S,5R)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-9H-purin-6-yl]-benzamide 
• 14985-44-5 8-bromo-2'-deoxyadenosine 
• 149540-21-6 5-(6-amino-8-bromo-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)tetrahydrofuran-3-ol 
• 98-88-4 benzoyl chloride 
• 958-09-8 2'-deoxy-D-adenosine 

Downstream Products

• 151203-55-3 N⁶-benzoyl-5'-O-<4,4'-dimethoxytrityl-8-amino(2-aminoethyl)>-2'-deoxyadenosine 
• 151322-48-4 N⁶-benzoyl-5'-O-(4,4'-dimethoxytrityl)-8-[2-(imidazol-4-yl)ethylamino]-2'-deoxyadenosine 
• 1093660-19-5 N₆-benzoyl-5'-O-(4,4'-dimethoxytrityl)-8-{2-[N-(4,4'-dimethoxytrityl)-4-imidazolyl]ethynyl}-2'-deoxyadenosine 
• 1093660-15-1 N₆-benzoyl-5'-O-(4,4'-dimethoxytrityl)-8-[(4-imidazolyl)methylamino]-2'-deoxyadenosine 
• 1093660-17-3 N₆-benzoyl-5'-O-(4,4'-dimethoxytrityl)-8-[(S)-1-methylcarboxy-2-(4-imidazolyl)ethylamino]-2'-deoxyadenosine 
• 1093660-16-2 N₆-benzoyl-5'-O-(4,4'-dimethoxytrityl)-8-[3-(4-imidazolyl)propylamino]-2'-deoxyadenosine 
• 1585977-31-6 6-N-benzoyl-5'-O-(4,4′-dimethoxytrityl)-8-(6-nitroveratrylthio)-2′-deoxyadenosine 
• 151545-38-9 3'-O-acetyl-N⁶-benzoyl-8-(1-N-acetylhistamino)-2'-deoxyadenosine 
• 151322-49-5 3'-O-acetyl-N⁶-benzoyl-8-amino(2-N-acetylaminoethyl)-2'-deoxyadenosine 
• 151322-50-8 C₆₀H₆₁ClN₉O₁₅P 

Relevant academic research and scientific papers

G-Tetraplex-Induced FRET within Telomeric Repeat Sequences Using PyA-PerA as Energy Donor-Acceptor Pair

G-tetraplex induced fluorescence resonance energy transfer (FRET) within telomeric repeat sequences has been studied using a nucleoside-tethered FRET pair embedded in the human telomeric G-quadruplex forming sequence (5′-A GGG TTPyA GGG TTPerA GGG TTA GGG-3′, Py=pyrene, Per=perylene). Conformational change from a single strand to an anti-parallel G-quadruplex leads to FRET from energy donor (PyA) to acceptor (PerA). The distance between the FRET donor/acceptor partners was controlled by changing the number of G-quartet spacer units. The FRET efficiency decreases with increase in G-quartet units. Overall findings indicate that this could be further used for the development of FRET-based sensing and measurement techniques.

Influence of Linker Length on Ligase-Catalyzed Oligonucleotide Polymerization

Ligase-catalyzed oligonucleotide polymerization (LOOPER) that enables the sequence-defined generation of DNA with up to 16 different modifications has recently been developed. This approach was used to develop new classes of diversely modified DNA aptamer

Synthesis and stability of oligodeoxynucleotides containing C8-labeled 2'-deoxyadenosine: novel redox nucleobase probes for DNA-mediated charge-transfer studies.

[reaction: see text] An efficient and convenient synthetic strategy to redox-labeled C8-derivatives of 2'-deoxyadenosine is described. The Pd(0) cross-coupling chemistry is amenable to both oxidative and reductive redox probes. The corresponding phosphoramidites of phenothiazine and anthraquinone nucleosides are amenable to automated DNA synthesis. The resulting labeled oligodeoxynucleotide strands form stable B-form duplexes with melting temperatures and CD spectra similar to those of the unlabeled analogues.

Synthesis and conformational studies of d(TpA) and r(UpA) conjugated with histamine and ethylenediamine

Dinucleotides (Figure 1b-d) possessing histamino/ethylenediamino substituents at C8 of adenine have been synthesised for modelling the molecular interactions that occur at catalytic site of nucleases. These compounds have been designed for putative molecular recognition of internucleotide phosphate by a complementary group (imidazole/-NH2) in the pendant C-8 side chains. 1H NMR spectroscopic analysis of synthesised model compounds indicate that C-8 modification leads to increase in percentage of S conformation of modified sugar while still maintaining an anti glycosyl torsion as in unmodified analog d(TpA). The C-8 side chain functionality (histamine/ethylenediamine) is probably involved in intramolecular interaction (electrostatic/ hydrogen bond) with the phosphate and/or 2′OH in (14). Such predisposition of side chain catalytic groups is important in developing appropriate models for active site of nucleases.