1-(5-amino-4-chloro-2-fluorophenyl)-7-chloro-2-methyl-1, 4-dihydro-4-oxo-1, 8-naphthyridine

Base Information

Chemical Name:1-(5-amino-4-chloro-2-fluorophenyl)-7-chloro-2-methyl-1, 4-dihydro-4-oxo-1, 8-naphthyridine
CAS No.:1315180-33-6
Molecular Formula:C₁₅H₁₀Cl₂FN₃O
Molecular Weight:338.168
Hs Code.:

Synonyms:1-(5-amino-4-chloro-2-fluorophenyl)-7-chloro-2-methyl-1, 4-dihydro-4-oxo-1, 8-naphthyridine

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Chemical Property of 1-(5-amino-4-chloro-2-fluorophenyl)-7-chloro-2-methyl-1, 4-dihydro-4-oxo-1, 8-naphthyridine

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Technology Process of 1-(5-amino-4-chloro-2-fluorophenyl)-7-chloro-2-methyl-1, 4-dihydro-4-oxo-1, 8-naphthyridine

There total 4 articles about 1-(5-amino-4-chloro-2-fluorophenyl)-7-chloro-2-methyl-1, 4-dihydro-4-oxo-1, 8-naphthyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1315180-32-5
C₁₅H₁₁Cl₃FN₃O

: 1315180-33-6
1-(5-amino-4-chloro-2-fluorophenyl)-7-chloro-2-methyl-1, 4-dihydro-4-oxo-1, 8-naphthyridine

Guidance literature:: With potassium carbonate; In dimethyl sulfoxide; at 80 ℃; for 1.5h;

Reference yield:

: 1315179-94-2
(E)-1-(2, 6-dichloropyridin-3-yl)-3-dimethylamino-2-buten-1-one

: 1315180-33-6
1-(5-amino-4-chloro-2-fluorophenyl)-7-chloro-2-methyl-1, 4-dihydro-4-oxo-1, 8-naphthyridine

Guidance literature:: Multi-step reaction with 3 steps

1: acetic acid / 5 h / 60 - 70 °C

2: ethanol; water; ammonium chloride; iron / 0.33 h / Reflux

3: potassium carbonate / dimethyl sulfoxide / 1.5 h / 80 °C

With ethanol; water; iron; potassium carbonate; ammonium chloride; acetic acid; In dimethyl sulfoxide;

Reference yield:

: 412018-50-9
1-(4,6-dichloropyridin-3-yl)ethan-1-one

: 1315180-33-6
1-(5-amino-4-chloro-2-fluorophenyl)-7-chloro-2-methyl-1, 4-dihydro-4-oxo-1, 8-naphthyridine

Guidance literature:: Multi-step reaction with 4 steps

1: 2 h / Reflux

2: acetic acid / 5 h / 60 - 70 °C

3: ethanol; water; ammonium chloride; iron / 0.33 h / Reflux

4: potassium carbonate / dimethyl sulfoxide / 1.5 h / 80 °C

With ethanol; water; iron; potassium carbonate; ammonium chloride; acetic acid; In dimethyl sulfoxide;