4-({4-[1-(4-chlorophenyl)-1H-pyrazolo[3,4-c]pyridin-3-yl]morpholin-2-yl}methyl)-N-ethylpiperazine-1-carboxamide

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Chemical Name:4-({4-[1-(4-chlorophenyl)-1H-pyrazolo[3,4-c]pyridin-3-yl]morpholin-2-yl}methyl)-N-ethylpiperazine-1-carboxamide
CAS No.:1427588-51-9
Molecular Formula:C₂₄H₃₀ClN₇O₂
Molecular Weight:484.001
Hs Code.:

Synonyms:4-({4-[1-(4-chlorophenyl)-1H-pyrazolo[3,4-c]pyridin-3-yl]morpholin-2-yl}methyl)-N-ethylpiperazine-1-carboxamide

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Chemical Property of 4-({4-[1-(4-chlorophenyl)-1H-pyrazolo[3,4-c]pyridin-3-yl]morpholin-2-yl}methyl)-N-ethylpiperazine-1-carboxamide

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Technology Process of 4-({4-[1-(4-chlorophenyl)-1H-pyrazolo[3,4-c]pyridin-3-yl]morpholin-2-yl}methyl)-N-ethylpiperazine-1-carboxamide

There total 6 articles about 4-({4-[1-(4-chlorophenyl)-1H-pyrazolo[3,4-c]pyridin-3-yl]morpholin-2-yl}methyl)-N-ethylpiperazine-1-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 32315-10-9
bis(trichloromethyl) carbonate

: 4-[1-(4-chlorophenyl)-1H-pyrazolo[3,4-c]pyridin-3-yl]-2-(piperazin-1-ylmethyl) morpholine trihydrochloride

: 75-04-7,85404-22-4
ethylamine

: 1427588-51-9
4-({4-[1-(4-chlorophenyl)-1H-pyrazolo[3,4-c]pyridin-3-yl]morpholin-2-yl}methyl)-N-ethylpiperazine-1-carboxamide

Guidance literature:: bis(trichloromethyl) carbonate; ethylamine; With N-ethyl-N,N-diisopropylamine; In dichloromethane; for 1h;

4-[1-(4-chlorophenyl)-1H-pyrazolo[3,4-c]pyridin-3-yl]-2-(piperazin-1-ylmethyl) morpholine trihydrochloride; With N-ethyl-N,N-diisopropylamine; In dichloromethane; for 96h;

Reference yield:

: 55279-29-3
3-amino-pyridine-4-carbaldehyde

: 1427588-51-9
4-({4-[1-(4-chlorophenyl)-1H-pyrazolo[3,4-c]pyridin-3-yl]morpholin-2-yl}methyl)-N-ethylpiperazine-1-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium tris(acetoxy)borohydride / dichloromethane / 0.04 h / 60 °C / Microwave irradiation

2.1: sodium nitrite; acetic acid / water / 0.08 h / 0 °C

3.1: copper diacetate; pyridine / 1,2-dichloro-ethane

4.1: hydrogenchloride / ethanol; water / 18 h

5.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h

5.2: 96 h

With pyridine; hydrogenchloride; copper diacetate; sodium tris(acetoxy)borohydride; acetic acid; N-ethyl-N,N-diisopropylamine; sodium nitrite; In ethanol; dichloromethane; water; 1,2-dichloro-ethane;

Reference yield:

: 1427588-93-9
tert-butyl 4-({4-[(3-aminopyridin-4-yl)methyl]morpholin-2-yl}methyl)piperazine-1-carboxylate

: 1427588-51-9
4-({4-[1-(4-chlorophenyl)-1H-pyrazolo[3,4-c]pyridin-3-yl]morpholin-2-yl}methyl)-N-ethylpiperazine-1-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium nitrite; acetic acid / water / 0.08 h / 0 °C

2.1: copper diacetate; pyridine / 1,2-dichloro-ethane

3.1: hydrogenchloride / ethanol; water / 18 h

4.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h

4.2: 96 h

With pyridine; hydrogenchloride; copper diacetate; acetic acid; N-ethyl-N,N-diisopropylamine; sodium nitrite; In ethanol; dichloromethane; water; 1,2-dichloro-ethane;