(2S,3R)-7-azido-1-cyclohexyl-2-<<(1,1-dimethylethoxy)carbonyl>amino>-3-hydroxy-4-oxoheptane

Base Information

Chemical Name:(2S,3R)-7-azido-1-cyclohexyl-2-<<(1,1-dimethylethoxy)carbonyl>amino>-3-hydroxy-4-oxoheptane
CAS No.:134848-85-4
Molecular Formula:C₁₈H₃₂N₄O₄
Molecular Weight:368.476
Hs Code.:

Synonyms:(2S,3R)-7-azido-1-cyclohexyl-2-<<(1,1-dimethylethoxy)carbonyl>amino>-3-hydroxy-4-oxoheptane

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Chemical Property of (2S,3R)-7-azido-1-cyclohexyl-2-<<(1,1-dimethylethoxy)carbonyl>amino>-3-hydroxy-4-oxoheptane

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Technology Process of (2S,3R)-7-azido-1-cyclohexyl-2-<<(1,1-dimethylethoxy)carbonyl>amino>-3-hydroxy-4-oxoheptane

There total 6 articles about (2S,3R)-7-azido-1-cyclohexyl-2-<<(1,1-dimethylethoxy)carbonyl>amino>-3-hydroxy-4-oxoheptane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: (2S,3R)-2-Amino-7-azido-1-cyclohexyl-3-hydroxy-heptan-4-one

: 134848-85-4
(2S,3R)-7-azido-1-cyclohexyl-2-<<(1,1-dimethylethoxy)carbonyl>amino>-3-hydroxy-4-oxoheptane

Guidance literature:: With sodium hydrogencarbonate; In tetrahydrofuran; water; at 4 ℃; Yield given;
DOI:10.1021/jm00113a005

Reference yield:

: 134848-81-0
(4S,5R)-4-(cyclohexylmethyl)-5-<2-(3-hydroxypropyl)-1,3-dioxolan-2-yl>-2-oxazolidinone

: 134848-85-4
(2S,3R)-7-azido-1-cyclohexyl-2-<<(1,1-dimethylethoxy)carbonyl>amino>-3-hydroxy-4-oxoheptane

Guidance literature:: Multi-step reaction with 5 steps

1: Et₃N / CH₂Cl₂ / 0.5 h / 0 °C

2: LiN₃ / dimethylformamide / Ambient temperature

3: 992 mg / Ba(OH)2 / dioxane; H₂O / Heating

4: 1 N aq. HCl / 60 - 65 °C

5: NaHCO₃ / tetrahydrofuran; H₂O / 4 °C

With hydrogenchloride; barium dihydroxide; lithium azide; sodium hydrogencarbonate; triethylamine; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/jm00113a005

Reference yield:

: 134848-99-0
(1R,2S)-2-Amino-1-[2-(3-azido-propyl)-[1,3]dioxolan-2-yl]-3-cyclohexyl-propan-1-ol

: 134848-85-4
(2S,3R)-7-azido-1-cyclohexyl-2-<<(1,1-dimethylethoxy)carbonyl>amino>-3-hydroxy-4-oxoheptane

Guidance literature:: Multi-step reaction with 2 steps

1: 1 N aq. HCl / 60 - 65 °C

2: NaHCO₃ / tetrahydrofuran; H₂O / 4 °C

With hydrogenchloride; sodium hydrogencarbonate; In tetrahydrofuran; water;
DOI:10.1021/jm00113a005