diethyl 3-(N-hydroxyacetamido)-1-(2-(hydroxymethyl)phenyl)propylphosphonate

Base Information

Chemical Name:diethyl 3-(N-hydroxyacetamido)-1-(2-(hydroxymethyl)phenyl)propylphosphonate
CAS No.:1313733-95-7
Molecular Formula:C₁₆H₂₆NO₆P
Molecular Weight:359.359
Hs Code.:

Synonyms:diethyl 3-(N-hydroxyacetamido)-1-(2-(hydroxymethyl)phenyl)propylphosphonate

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Chemical Property of diethyl 3-(N-hydroxyacetamido)-1-(2-(hydroxymethyl)phenyl)propylphosphonate

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Technology Process of diethyl 3-(N-hydroxyacetamido)-1-(2-(hydroxymethyl)phenyl)propylphosphonate

There total 5 articles about diethyl 3-(N-hydroxyacetamido)-1-(2-(hydroxymethyl)phenyl)propylphosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1313733-78-6
diethyl 1-(2-(benzyloxymethyl)phenyl)-3-oxopropylphosphonate

: 1313733-95-7
diethyl 3-(N-hydroxyacetamido)-1-(2-(hydroxymethyl)phenyl)propylphosphonate

Guidance literature:: Multi-step reaction with 3 steps

1.1: pyridine; ethanol / 20 °C

1.2: 0.5 h / 20 °C

1.3: 2 h / 0 - 20 °C

2.1: triethylamine / dichloromethane / 3 h / 20 °C

3.1: palladium 10% on activated carbon; hydrogen / methanol / 5 h / Cooling with ice

With palladium 10% on activated carbon; hydrogen; triethylamine; In pyridine; methanol; ethanol; dichloromethane;
DOI:10.1021/jm2000085

Reference yield:

: 1313733-75-3
(E)-3-(2-(benzyloxymethyl)phenyl)acrylaldehyde

: 1313733-95-7
diethyl 3-(N-hydroxyacetamido)-1-(2-(hydroxymethyl)phenyl)propylphosphonate

Guidance literature:: Multi-step reaction with 4 steps

1.1: phenol / 4 h / 100 °C

1.2: 24 h / Reflux

2.1: pyridine; ethanol / 20 °C

2.2: 0.5 h / 20 °C

2.3: 2 h / 0 - 20 °C

3.1: triethylamine / dichloromethane / 3 h / 20 °C

4.1: palladium 10% on activated carbon; hydrogen / methanol / 5 h / Cooling with ice

With palladium 10% on activated carbon; hydrogen; triethylamine; phenol; In pyridine; methanol; ethanol; dichloromethane;
DOI:10.1021/jm2000085

Reference yield:

: C₂₈H₃₆NO₅P

: 1313733-95-7
diethyl 3-(N-hydroxyacetamido)-1-(2-(hydroxymethyl)phenyl)propylphosphonate

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 3 h / 20 °C

2: palladium 10% on activated carbon; hydrogen / methanol / 5 h / Cooling with ice

With palladium 10% on activated carbon; hydrogen; triethylamine; In methanol; dichloromethane;
DOI:10.1021/jm2000085