3-(N-hydroxyacetamido)-1-(2-(methoxymethyl)phenyl)propylphosphonic acid

Base Information

• Chemical Name: 3-(N-hydroxyacetamido)-1-(2-(methoxymethyl)phenyl)propylphosphonic acid
• CAS No.: 1313734-08-5
• Molecular Formula: C₁₃H₂₀NO₆P
• Molecular Weight: 317.279
• Mol file: 1313734-08-5.mol

Synonyms:3-(N-hydroxyacetamido)-1-(2-(methoxymethyl)phenyl)propylphosphonic acid

Chemical Property of 3-(N-hydroxyacetamido)-1-(2-(methoxymethyl)phenyl)propylphosphonic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(N-hydroxyacetamido)-1-(2-(methoxymethyl)phenyl)propylphosphonic acid

There total 5 articles about 3-(N-hydroxyacetamido)-1-(2-(methoxymethyl)phenyl)propylphosphonic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

methanol (67-56-1) + diethyl 3-(N-hydroxyacetamido)-1-(2-(hydroxymethyl)phenyl)propylphosphonate (1313733-95-7) → 3-(N-hydroxyacetamido)-1-(2-(methoxymethyl)phenyl)propylphosphonic acid (1313734-08-5)

Guidance literature:

diethyl 3-(N-hydroxyacetamido)-1-(2-(hydroxymethyl)phenyl)propylphosphonate; With trimethylsilyl bromide; In dichloromethane; at 20 ℃; for 24h; Inert atmosphere;

methanol;

DOI:10.1021/jm2000085

Reference yield:

diethyl 1-(2-(benzyloxymethyl)phenyl)-3-oxopropylphosphonate (1313733-78-6) → 3-(N-hydroxyacetamido)-1-(2-(methoxymethyl)phenyl)propylphosphonic acid (1313734-08-5)

Guidance literature:

Multi-step reaction with 4 steps

1.1: pyridine; ethanol / 20 °C

1.2: 0.5 h / 20 °C

1.3: 2 h / 0 - 20 °C

2.1: triethylamine / dichloromethane / 3 h / 20 °C

3.1: palladium 10% on activated carbon; hydrogen / methanol / 5 h / Cooling with ice

4.1: trimethylsilyl bromide / dichloromethane / 24 h / 20 °C / Inert atmosphere

With trimethylsilyl bromide; palladium 10% on activated carbon; hydrogen; triethylamine; In pyridine; methanol; ethanol; dichloromethane;

DOI:10.1021/jm2000085

Reference yield:

C30H38NO6P (1313733-93-5) → 3-(N-hydroxyacetamido)-1-(2-(methoxymethyl)phenyl)propylphosphonic acid (1313734-08-5)

Guidance literature:

Multi-step reaction with 2 steps

1: palladium 10% on activated carbon; hydrogen / methanol / 5 h / Cooling with ice

2: trimethylsilyl bromide / dichloromethane / 24 h / 20 °C / Inert atmosphere

With trimethylsilyl bromide; palladium 10% on activated carbon; hydrogen; In methanol; dichloromethane;

DOI:10.1021/jm2000085

upstream raw materials:

methanol

diethyl 3-(N-hydroxyacetamido)-1-(2-(hydroxymethyl)phenyl)propylphosphonate

diethyl 1-(2-(benzyloxymethyl)phenyl)-3-oxopropylphosphonate

C₃₀H₃₈NO₆P