(3S,4R)-benzyl 3-((tert-butoxycarbonyl)amino)-4-hydroxypiperidine-1-carboxylate

Base Information

• Chemical Name: (3S,4R)-benzyl 3-((tert-butoxycarbonyl)amino)-4-hydroxypiperidine-1-carboxylate
• CAS No.: 1549812-65-8
• Molecular Formula: C₁₈H₂₆N₂O₅
• Molecular Weight: 350.415

Synonyms:(3S,4R)-benzyl 3-((tert-butoxycarbonyl)amino)-4-hydroxypiperidine-1-carboxylate

Chemical Property of (3S,4R)-benzyl 3-((tert-butoxycarbonyl)amino)-4-hydroxypiperidine-1-carboxylate

Chemical Property:

• Boiling Point: 512.9±50.0 °C(Predicted)
• Density: 1.22±0.1 g/cm3(Predicted)

Purity/Quality:

99%, ^*data from raw suppliers

(3S,4R)-benzyl3-((tert-butoxycarbonyl)amino)-4-hydroxypiperidine-1-carboxylate 95%-98% ^*data from reagent suppliers

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Technology Process of (3S,4R)-benzyl 3-((tert-butoxycarbonyl)amino)-4-hydroxypiperidine-1-carboxylate

There total 13 articles about (3S,4R)-benzyl 3-((tert-butoxycarbonyl)amino)-4-hydroxypiperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.48%

(3R,4S)-benzyl 3-((tert-butoxycarbonyl)amino)-4-hydroxypiperidine-1-carboxylate (859854-67-4,1549812-60-3) → (3S,4R)-benzyl 3-((tert-butoxycarbonyl)amino)-4-hydroxypiperidine-1-carboxylate (1549812-65-8,859854-67-4,1549812-60-3) + (3R,4S)-benzyl 3-((tert-butoxycarbonyl)amino)-4-hydroxypiperidine-1-carboxylate (859854-67-4,1549812-60-3)

Guidance literature:

With Chiralpak AD-H; In ethanol; hexane; Resolution of racemate;

Reference yield: 31.0%

cis-benzyl 3-{[(tert-butoxy)carbonyl]amino}-4-hydroxypiperidine-1-carboxylate (859854-67-4,1549812-60-3) → (3S,4R)-benzyl 3-((tert-butoxycarbonyl)amino)-4-hydroxypiperidine-1-carboxylate (1549812-65-8,859854-67-4,1549812-60-3) + (3R,4S)-benzyl 3-((tert-butoxycarbonyl)amino)-4-hydroxypiperidine-1-carboxylate (859854-67-4,1549812-60-3)

Guidance literature:

With Chiralpak AD; In ethanol; hexane; Reagent/catalyst; Resolution of racemate;

Reference yield: 6.48%

3-tert-butoxycarbonylamino-4-hydroxypiperidine-1-carboxylic acid benzyl ester (859854-67-4,1549812-60-3) → (3S,4R)-benzyl 3-((tert-butoxycarbonyl)amino)-4-hydroxypiperidine-1-carboxylate (1549812-65-8,859854-67-4,1549812-60-3) + (3R,4S)-benzyl 3-((tert-butoxycarbonyl)amino)-4-hydroxypiperidine-1-carboxylate (859854-67-4,1549812-60-3)

Guidance literature:

With Chiralpak AD-H, 250 x 30mm, 5 pm [ADH₁₀₀₂₉-01]; In ethanol; hexane; at 20 ℃; Resolution of racemate;

upstream raw materials:

3,4-epoxy-piperidine-1-carboxylic acid benzyl ester

1-benzyloxycarbonyl-1,2,3,6-tetrahydropyridine

(trans)-benzyl 3-((tert-butoxycarbonyl)amino)-4-hydroxypiperidine-1-carboxylate

3-tert-butoxycarbonylamino-4-hydroxypiperidine-1-carboxylic acid benzyl ester

Downstream raw materials:

tert-butyl ((3S,4R)-4-hydroxypiperidin-3-yl)carbamate

C₁₃H₁₈N₂O₃

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