3,5-dimethoxy-4-(2-amino-3-prop-2-ynylsulfanylpropionyl)benzoic acid 4-guanidinobutyl ester

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Chemical Name:3,5-dimethoxy-4-(2-amino-3-prop-2-ynylsulfanylpropionyl)benzoic acid 4-guanidinobutyl ester
CAS No.:1315318-70-7
Molecular Formula:C₂₀H₂₈N₄O₆S
Molecular Weight:452.532
Hs Code.:

Synonyms:3,5-dimethoxy-4-(2-amino-3-prop-2-ynylsulfanylpropionyl)benzoic acid 4-guanidinobutyl ester

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Chemical Property of 3,5-dimethoxy-4-(2-amino-3-prop-2-ynylsulfanylpropionyl)benzoic acid 4-guanidinobutyl ester

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Technology Process of 3,5-dimethoxy-4-(2-amino-3-prop-2-ynylsulfanylpropionyl)benzoic acid 4-guanidinobutyl ester

There total 6 articles about 3,5-dimethoxy-4-(2-amino-3-prop-2-ynylsulfanylpropionyl)benzoic acid 4-guanidinobutyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 1315318-67-2
(R)-4-(2,3-bis(tert-butoxycarbonyl)guanidino)butyl 4-((2-((tert-butoxycarbonyl)amino)-3-(prop-2-yn-1-ylthio)propanoyl)oxy)-3,5-dimethoxybenzoate

: 1315318-70-7
3,5-dimethoxy-4-(2-amino-3-prop-2-ynylsulfanylpropionyl)benzoic acid 4-guanidinobutyl ester

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 0 - 25 ℃; for 8h; Inert atmosphere;
DOI:10.1021/acschemneuro.1c00200

Reference yield:

: 1260119-24-1
3,5-dimethoxy-4-hydroxybenzoic acid-4-(N,N'-diBoc-guanidino)butyl ester

: 1315318-70-7
3,5-dimethoxy-4-(2-amino-3-prop-2-ynylsulfanylpropionyl)benzoic acid 4-guanidinobutyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 4-(dimethylamino)pyridinium tosylate; diisopropyl-carbodiimide / dichloromethane / 3 h / 30 °C / Inert atmosphere

2: trifluoroacetic acid / dichloromethane / 8 h / 0 - 25 °C / Inert atmosphere

With 4-(dimethylamino)pyridinium tosylate; trifluoroacetic acid; diisopropyl-carbodiimide; In dichloromethane;
DOI:10.1021/acschemneuro.1c00200

Reference yield:

: 530-57-4
3,5-dimethoxy-4-hydroxybenzoic acid

: 1315318-70-7
3,5-dimethoxy-4-(2-amino-3-prop-2-ynylsulfanylpropionyl)benzoic acid 4-guanidinobutyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 2 h / 140 °C / Inert atmosphere

2: 4-(dimethylamino)pyridinium tosylate; diisopropyl-carbodiimide / dichloromethane / 5 h / 25 °C / Inert atmosphere

3: sodium methylate; methanol / dichloromethane / 5 h / 4 °C / Inert atmosphere

4: 4-(dimethylamino)pyridinium tosylate; diisopropyl-carbodiimide / dichloromethane / 3 h / 30 °C / Inert atmosphere

5: trifluoroacetic acid / dichloromethane / 8 h / 0 - 25 °C / Inert atmosphere

With methanol; sodium methylate; 4-(dimethylamino)pyridinium tosylate; trifluoroacetic acid; diisopropyl-carbodiimide; In dichloromethane;
DOI:10.1021/acschemneuro.1c00200