C₃₀H₃₅F₃O₈S

Base Information

• Chemical Name: C₃₀H₃₅F₃O₈S
• CAS No.: 342902-11-8
• Molecular Formula: C₃₀H₃₅F₃O₈S
• Molecular Weight: 612.664
• Mol file: 342902-11-8.mol

Synonyms:C₃₀H₃₅F₃O₈S

Chemical Property of C₃₀H₃₅F₃O₈S

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₃₀H₃₅F₃O₈S

There total 15 articles about C₃₀H₃₅F₃O₈S which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

N,N-phenylbistrifluoromethane-sulfonimide (37595-74-7) + C29H36O6 (342902-00-5) → C30H35F3O8S (342902-11-8)

Guidance literature:

In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; at -78 ℃;

DOI:10.1002/1521-3773(20010316)40:6<1090::AID-ANIE10900>3.0.CO;2-W

Reference yield:

(3R,3aR,5S,6S,7S,7aS)-7-Benzyloxy-5-methoxy-3,6-dimethyl-hexahydro-furo[3,2-b]pyran-2-one (157219-94-8) → C30H35F3O8S (342902-11-8)

Guidance literature:

Multi-step reaction with 15 steps

1.1: DIABLH / CH₂Cl₂ / -78 °C

1.2: NaBH₄ / methanol / 0 °C

2.1: Et₃N; DMAP / CH₂Cl₂ / 20 °C

3.1: dimethylsulfoxide / 70 °C

3.2: Mg / methanol / 20 °C

3.3: 83 percent / imidazole / dimethylformamide / 20 °C

4.1: DIABLH / CH₂Cl₂ / -78 °C

4.2: AcOH / tetrahydrofuran; H₂O / 20 °C

4.3: 78 percent / tetrapropylammonium perruthenate; N-methylmorpholine N-oxide; 4 Angstroem molecular sieves / CH₂Cl₂ / 20 °C

5.1: 82 percent / LiHMDS / tetrahydrofuran / -78 °C

6.1: 68 percent / tetrahydrofuran / -78 °C

7.1: OsO₄; N,N'-bis(2,4,6-triMe-Bn)-(S,S)-1,2-diPh-1,2-diaminoethane / CH₂Cl₂ / -90 °C

7.2: NaHSO₃ / tetrahydrofuran; H₂O / 70 °C

7.3: 79 percent / camphorsulfonic acid / benzene / 20 °C

8.1: 98 percent / NaH / dimethylformamide / 20 °C

9.1: BF₃*Et₂O; Me₂S / CH₂Cl₂ / 0 °C

9.2: NaHMDS / tetrahydrofuran / 40 °C

10.1: 2,6-lutidine / CH₂Cl₂ / 20 °C

11.1: 9-BBN / tetrahydrofuran / 20 - 40 °C

11.2: 98 percent / NaOH; H₂O₂ / H₂O / 20 °C

12.1: SO₃*pyridine; Et₃N / CH₂Cl₂; dimethylsulfoxide / 0 °C

12.2: NaClO₂; KH₂PO₄; 2-methyl-2-butene / 2-methyl-propan-2-ol; H₂O / 20 °C

13.1: 0.5 M HCl / tetrahydrofuran / 20 °C

14.1: 2,4,6-trichlorobenzoyl chloride; Et₃N / tetrahydrofuran

14.2: 93 percent / DMAP / benzene / Heating

15.1: 88 percent / tetrahydrofuran; hexamethylphosphoric acid triamide / -78 °C

With 2,6-dimethylpyridine; hydrogenchloride; dmap; osmium(VIII) oxide; 9-borabicyclo[3.3.1]nonane dimer; pyridine-SO₃ complex; dimethylsulfide; 2,4,6-trichlorobenzoyl chloride; boron trifluoride diethyl etherate; sodium hydride; (1S,2S)-1,2-diphenyl-N¹,N²-bis(mesitylmethyl)ethane-1,2-diamine; triethylamine; lithium hexamethyldisilazane; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; 6.1: Grignard reaction / 9.2: Wittig reaction;

DOI:10.1002/1521-3773(20010316)40:6<1090::AID-ANIE10900>3.0.CO;2-W

Reference yield:

(2R,3S,4S,5S,6S)-4-Benzyloxy-2-((S)-2-hydroxy-1-methyl-ethyl)-6-methoxy-5-methyl-tetrahydro-pyran-3-ol → C30H35F3O8S (342902-11-8)

Guidance literature:

Multi-step reaction with 14 steps

1.1: Et₃N; DMAP / CH₂Cl₂ / 20 °C

2.1: dimethylsulfoxide / 70 °C

2.2: Mg / methanol / 20 °C

2.3: 83 percent / imidazole / dimethylformamide / 20 °C

3.1: DIABLH / CH₂Cl₂ / -78 °C

3.2: AcOH / tetrahydrofuran; H₂O / 20 °C

3.3: 78 percent / tetrapropylammonium perruthenate; N-methylmorpholine N-oxide; 4 Angstroem molecular sieves / CH₂Cl₂ / 20 °C

4.1: 82 percent / LiHMDS / tetrahydrofuran / -78 °C

5.1: 68 percent / tetrahydrofuran / -78 °C

6.1: OsO₄; N,N'-bis(2,4,6-triMe-Bn)-(S,S)-1,2-diPh-1,2-diaminoethane / CH₂Cl₂ / -90 °C

6.2: NaHSO₃ / tetrahydrofuran; H₂O / 70 °C

6.3: 79 percent / camphorsulfonic acid / benzene / 20 °C

7.1: 98 percent / NaH / dimethylformamide / 20 °C

8.1: BF₃*Et₂O; Me₂S / CH₂Cl₂ / 0 °C

8.2: NaHMDS / tetrahydrofuran / 40 °C

9.1: 2,6-lutidine / CH₂Cl₂ / 20 °C

10.1: 9-BBN / tetrahydrofuran / 20 - 40 °C

10.2: 98 percent / NaOH; H₂O₂ / H₂O / 20 °C

11.1: SO₃*pyridine; Et₃N / CH₂Cl₂; dimethylsulfoxide / 0 °C

11.2: NaClO₂; KH₂PO₄; 2-methyl-2-butene / 2-methyl-propan-2-ol; H₂O / 20 °C

12.1: 0.5 M HCl / tetrahydrofuran / 20 °C

13.1: 2,4,6-trichlorobenzoyl chloride; Et₃N / tetrahydrofuran

13.2: 93 percent / DMAP / benzene / Heating

14.1: 88 percent / tetrahydrofuran; hexamethylphosphoric acid triamide / -78 °C

With 2,6-dimethylpyridine; hydrogenchloride; dmap; osmium(VIII) oxide; 9-borabicyclo[3.3.1]nonane dimer; pyridine-SO₃ complex; dimethylsulfide; 2,4,6-trichlorobenzoyl chloride; boron trifluoride diethyl etherate; sodium hydride; (1S,2S)-1,2-diphenyl-N¹,N²-bis(mesitylmethyl)ethane-1,2-diamine; triethylamine; lithium hexamethyldisilazane; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; 5.1: Grignard reaction / 8.2: Wittig reaction;

DOI:10.1002/1521-3773(20010316)40:6<1090::AID-ANIE10900>3.0.CO;2-W

upstream raw materials:

N,N-phenylbistrifluoromethane-sulfonimide

C₂₉H₃₆O₆

(3R,3aR,5S,6S,7S,7aS)-7-Benzyloxy-5-methoxy-3,6-dimethyl-hexahydro-furo[3,2-b]pyran-2-one

(4S,4aR,6S,7S,8S,8aS)-8-Benzyloxy-6-methoxy-4,7-dimethyl-hexahydro-pyrano[3,2-b]pyran-2-one

Downstream raw materials:

C₇₅H₁₀₂O₁₃Si

C₇₁H₉₀O₁₂S

C₇₅H₁₀₀O₁₂Si