(1'R,2'S,2R)-2-phenylcyclohexyl 2-(4-fluorophenyl)-2-hydroxy-3-trimethylsilylpropionate

Base Information

Chemical Name:(1'R,2'S,2R)-2-phenylcyclohexyl 2-(4-fluorophenyl)-2-hydroxy-3-trimethylsilylpropionate
CAS No.:168253-64-3
Molecular Formula:C₂₄H₃₁FO₃Si
Molecular Weight:414.592
Hs Code.:

Synonyms:(1'R,2'S,2R)-2-phenylcyclohexyl 2-(4-fluorophenyl)-2-hydroxy-3-trimethylsilylpropionate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1'R,2'S,2R)-2-phenylcyclohexyl 2-(4-fluorophenyl)-2-hydroxy-3-trimethylsilylpropionate

Chemical Property:

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Technology Process of (1'R,2'S,2R)-2-phenylcyclohexyl 2-(4-fluorophenyl)-2-hydroxy-3-trimethylsilylpropionate

There total 3 articles about (1'R,2'S,2R)-2-phenylcyclohexyl 2-(4-fluorophenyl)-2-hydroxy-3-trimethylsilylpropionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 13170-43-9
(trimethylsilyl)methylmagnesium chloride

: 168125-45-9
2-phenylcyclohexyl 2-(4-fluorophenyl)glyoxylate

: 168253-64-3
(1'R,2'S,2R)-2-phenylcyclohexyl 2-(4-fluorophenyl)-2-hydroxy-3-trimethylsilylpropionate

: (1'R,2'S,2S)-2-phenylcyclohexyl 2-(4-fluorophenyl)-2-hydroxy-3-trimethylsilylpropionate

Guidance literature:: In diethyl ether; at -70 ℃; for 1h;
DOI:10.1016/j.bmc.2004.04.027

Reference yield:

: 98919-68-7
(1R,2S)-trans-2-phenylcyclohexanol

: 168253-64-3
(1'R,2'S,2R)-2-phenylcyclohexyl 2-(4-fluorophenyl)-2-hydroxy-3-trimethylsilylpropionate

Guidance literature:: Multi-step reaction with 2 steps

1.1: oxalyl chloride / CH₂Cl₂ / 3 h / 20 °C

1.2: 91 percent / acetonitrile / 3 h / 20 °C

2.1: 50 percent / diethyl ether / 1 h / -70 °C

With oxalyl dichloride; In diethyl ether; dichloromethane; 2.1: Grignard reaction;
DOI:10.1016/j.bmc.2004.04.027

Reference yield:

: 2251-76-5
2-(4-fluorophenyl)-2-oxoacetic acid

: 168253-64-3
(1'R,2'S,2R)-2-phenylcyclohexyl 2-(4-fluorophenyl)-2-hydroxy-3-trimethylsilylpropionate

Guidance literature:: Multi-step reaction with 2 steps

1.1: oxalyl chloride / CH₂Cl₂ / 3 h / 20 °C

1.2: 91 percent / acetonitrile / 3 h / 20 °C

2.1: 50 percent / diethyl ether / 1 h / -70 °C

With oxalyl dichloride; In diethyl ether; dichloromethane; 2.1: Grignard reaction;
DOI:10.1016/j.bmc.2004.04.027