1-(4-methoxyphenyl)-3-phenylpropan-2-yl 2-diazo-2-(diethoxy-phosphoryl)acetate

Base Information

Chemical Name:1-(4-methoxyphenyl)-3-phenylpropan-2-yl 2-diazo-2-(diethoxy-phosphoryl)acetate
CAS No.:1607455-12-8
Molecular Formula:C₂₂H₂₇N₂O₆P
Molecular Weight:446.44
Hs Code.:

Synonyms:1-(4-methoxyphenyl)-3-phenylpropan-2-yl 2-diazo-2-(diethoxy-phosphoryl)acetate

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Chemical Property of 1-(4-methoxyphenyl)-3-phenylpropan-2-yl 2-diazo-2-(diethoxy-phosphoryl)acetate

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Technology Process of 1-(4-methoxyphenyl)-3-phenylpropan-2-yl 2-diazo-2-(diethoxy-phosphoryl)acetate

There total 4 articles about 1-(4-methoxyphenyl)-3-phenylpropan-2-yl 2-diazo-2-(diethoxy-phosphoryl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 1607455-51-5
1-(4-methoxyphenyl)-3-phenylpropan-2-yl 2-(diethoxyphosphoryl)acetate

: 1607455-12-8
1-(4-methoxyphenyl)-3-phenylpropan-2-yl 2-diazo-2-(diethoxy-phosphoryl)acetate

Guidance literature:: 1-(4-methoxyphenyl)-3-phenylpropan-2-yl 2-(diethoxyphosphoryl)acetate; With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 - 20 ℃; for 0.166667h; Inert atmosphere;

With 4-acetamidobenzenesulfonyl azide; In tetrahydrofuran; at 20 ℃; for 1h; Inert atmosphere;
DOI:10.1021/ol501092m

Reference yield:

: 64764-53-0
1-(4-methoxyphenyl)-3-phenylpropan-2-ol

: 1607455-12-8
1-(4-methoxyphenyl)-3-phenylpropan-2-yl 2-diazo-2-(diethoxy-phosphoryl)acetate

Guidance literature:: Multi-step reaction with 2 steps

1.1: 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine / toluene; ethyl acetate / 4 h / 20 °C / Inert atmosphere

2.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.17 h / -78 - 20 °C / Inert atmosphere

2.2: 1 h / 20 °C / Inert atmosphere

With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine; lithium hexamethyldisilazane; In tetrahydrofuran; ethyl acetate; toluene;
DOI:10.1021/ol501092m

Reference yield:

: 5703-26-4
4-Methoxyphenylacetaldehyde

: 1607455-12-8
1-(4-methoxyphenyl)-3-phenylpropan-2-yl 2-diazo-2-(diethoxy-phosphoryl)acetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: tetrahydrofuran / 3 h / 0 °C / Inert atmosphere

2.1: 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine / toluene; ethyl acetate / 4 h / 20 °C / Inert atmosphere

3.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.17 h / -78 - 20 °C / Inert atmosphere

3.2: 1 h / 20 °C / Inert atmosphere

With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine; lithium hexamethyldisilazane; In tetrahydrofuran; ethyl acetate; toluene;
DOI:10.1021/ol501092m