N-acetyl-1-(3,4-dimethoxy)benzyl-1,2,3,4-tetrahydro-7-methoxyisoquinolin-6-ol

Base Information

• Chemical Name: N-acetyl-1-(3,4-dimethoxy)benzyl-1,2,3,4-tetrahydro-7-methoxyisoquinolin-6-ol
• CAS No.: 329772-77-2
• Molecular Formula: C₂₁H₂₅NO₅
• Molecular Weight: 371.433
• Mol file: 329772-77-2.mol

Synonyms:N-acetyl-1-(3,4-dimethoxy)benzyl-1,2,3,4-tetrahydro-7-methoxyisoquinolin-6-ol

Chemical Property of N-acetyl-1-(3,4-dimethoxy)benzyl-1,2,3,4-tetrahydro-7-methoxyisoquinolin-6-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-acetyl-1-(3,4-dimethoxy)benzyl-1,2,3,4-tetrahydro-7-methoxyisoquinolin-6-ol

There total 2 articles about N-acetyl-1-(3,4-dimethoxy)benzyl-1,2,3,4-tetrahydro-7-methoxyisoquinolin-6-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

N-acetyl-1-(3,4-dimethoxy)benzyl-1,2,3,4-tetrahydro-6-benzyloxy-7-methoxyisoquinoline (329772-72-7) → N-acetyl-1-(3,4-dimethoxy)benzyl-1,2,3,4-tetrahydro-7-methoxyisoquinolin-6-ol (329772-77-2)

Guidance literature:

With hydrogen; palladium on activated charcoal; In chloroform; ethyl acetate; at 20 ℃; for 2h; under 760 Torr;

DOI:10.1016/S0040-4020(00)00934-0

Reference yield:

1-(3,4-dimethoxy)benzyl-1,2,3,4-tetrahydro-6-benzyloxy-7-methoxyisoquinoline (54881-16-2) → N-acetyl-1-(3,4-dimethoxy)benzyl-1,2,3,4-tetrahydro-7-methoxyisoquinolin-6-ol (329772-77-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 51 percent / K₂CO₃ / CH₂Cl₂ / 1 h / 20 °C

2: 86 percent / H₂ / Pd/C / ethyl acetate; CHCl₃ / 2 h / 20 °C / 760 Torr

With hydrogen; potassium carbonate; palladium on activated charcoal; In dichloromethane; chloroform; ethyl acetate;

DOI:10.1016/S0040-4020(00)00934-0

Reference yield:

N-acetyl-1-(3,4-dimethoxy)benzyl-1,2,3,4-tetrahydro-7-methoxyisoquinolin-6-ol (329772-77-2) → N-[2-(3,4-dimethoxyphenyl)ethenyl]-N-[2-(2-acetoxy-5-hydroxy-4-methoxyphenyl)ethyl]acetamide

Guidance literature:

Multi-step reaction with 2 steps

1: CH₂Cl₂ / 0.5 h

2: 66.3 mg / 2 h / 30 - 40 °C

In dichloromethane;

DOI:10.1016/S0040-4020(00)00934-0

upstream raw materials:

N-acetyl-1-(3,4-dimethoxy)benzyl-1,2,3,4-tetrahydro-6-benzyloxy-7-methoxyisoquinoline

1-(3,4-dimethoxy)benzyl-1,2,3,4-tetrahydro-6-benzyloxy-7-methoxyisoquinoline

Downstream raw materials:

N-acetyl-1-(3,4-dimethoxy)benzyl-7-acetoxy-1,2,3,4,6,7-hexahydro-7-methoxy-6-oxoisoquinoline