4-(4-fluorophenyl)-5-methyl-2-(1-methylethyl)-6-phenyl-3-pyridinemethanol

Base Information

Chemical Name:4-(4-fluorophenyl)-5-methyl-2-(1-methylethyl)-6-phenyl-3-pyridinemethanol
CAS No.:135426-23-2
Molecular Formula:C₂₂H₂₂FNO
Molecular Weight:335.421
Hs Code.:

Synonyms:4-(4-fluorophenyl)-5-methyl-2-(1-methylethyl)-6-phenyl-3-pyridinemethanol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-(4-fluorophenyl)-5-methyl-2-(1-methylethyl)-6-phenyl-3-pyridinemethanol

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Technology Process of 4-(4-fluorophenyl)-5-methyl-2-(1-methylethyl)-6-phenyl-3-pyridinemethanol

There total 5 articles about 4-(4-fluorophenyl)-5-methyl-2-(1-methylethyl)-6-phenyl-3-pyridinemethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 135427-10-0
4-(4-fluorophenyl)-5-methyl-2-(1-methylethyl)-6-phenyl-3-pyridinecarboxylic acid ethyl ester

: 135426-23-2
4-(4-fluorophenyl)-5-methyl-2-(1-methylethyl)-6-phenyl-3-pyridinemethanol

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; for 6h; Ambient temperature;
DOI:10.1021/jm00113a019

Reference yield:

: 459-57-4
4-fluorobenzaldehyde

: 135426-23-2
4-(4-fluorophenyl)-5-methyl-2-(1-methylethyl)-6-phenyl-3-pyridinemethanol

Guidance literature:: Multi-step reaction with 4 steps

1: piperidine, HOAc / benzene / 22 h / Heating

2: 1.) LiN(TMS)2 / 1.) THF, -78 deg C, 1 h, 2.) THF, 1.5 h

3: 87 percent / NH₄OAc, Cu(OAc)2 / acetic acid / 24 h / Heating

4: 92 percent / LiAlH₄ / tetrahydrofuran / 6 h / Ambient temperature

With piperidine; lithium aluminium tetrahydride; copper diacetate; ammonium acetate; acetic acid; lithium hexamethyldisilazane; In tetrahydrofuran; acetic acid; benzene;
DOI:10.1021/jm00113a019

Reference yield:

: 135427-07-5
β-(4-fluorophenyl)-α-(2-methyl-1-oxopropyl)-δ-oxobenzenepentanoic acid ethyl ester

: 135426-23-2
4-(4-fluorophenyl)-5-methyl-2-(1-methylethyl)-6-phenyl-3-pyridinemethanol

Guidance literature:: Multi-step reaction with 2 steps

1: 87 percent / NH₄OAc, Cu(OAc)2 / acetic acid / 24 h / Heating

2: 92 percent / LiAlH₄ / tetrahydrofuran / 6 h / Ambient temperature

With lithium aluminium tetrahydride; copper diacetate; ammonium acetate; In tetrahydrofuran; acetic acid;
DOI:10.1021/jm00113a019