3-[benzyl(2-cyclopropylideneethyl)amino]-2,2-dimethylpropan-1-ol

Base Information

• Chemical Name: 3-[benzyl(2-cyclopropylideneethyl)amino]-2,2-dimethylpropan-1-ol
• CAS No.: 524018-57-3
• Molecular Formula: C₁₇H₂₅NO
• Molecular Weight: 259.392
• Mol file: 524018-57-3.mol

Synonyms:3-[benzyl(2-cyclopropylideneethyl)amino]-2,2-dimethylpropan-1-ol

Chemical Property of 3-[benzyl(2-cyclopropylideneethyl)amino]-2,2-dimethylpropan-1-ol

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 3-[benzyl(2-cyclopropylideneethyl)amino]-2,2-dimethylpropan-1-ol

There total 1 articles about 3-[benzyl(2-cyclopropylideneethyl)amino]-2,2-dimethylpropan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

1-tosyloxy-1-vinylcyclopropane (32364-41-3) + 3-(benzylamino)-2,2-dimethylpropan-1-ol (16047-87-3) → 3-[benzyl(2-cyclopropylideneethyl)amino]-2,2-dimethylpropan-1-ol (524018-57-3)

Guidance literature:

With TEA; triphenylphosphine; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In dichloromethane;

DOI:10.1021/jo034003g

Reference yield: 85.0%

3-[benzyl(2-cyclopropylideneethyl)amino]-2,2-dimethylpropan-1-ol (524018-57-3) → 3-[benzyl(2-cyclopropylideneethyl)amino]-2,2-dimethylpropanal (524018-58-4)

Guidance literature:

With N-methyl-2-indolinone; tetrapropylammonium perruthennate; 4 A molecular sieve; In dichloromethane; at 20 ℃; for 1h;

DOI:10.1021/jo034003g

Reference yield:

3-[benzyl(2-cyclopropylideneethyl)amino]-2,2-dimethylpropan-1-ol (524018-57-3) → (4aS,8aR)-6-Benzyl-1,8,8-trimethyl-octahydro-[1,6]naphthyridin-4-one

Guidance literature:

Multi-step reaction with 3 steps

1: 85 percent / molecular sieves 4 Angstroem; NMO; TPAP / CH₂Cl₂ / 1 h / 20 °C

2: 40 percent / TEA / toluene / 20 °C

3: 40 percent / xylene / 5 h / 140 °C

With N-methyl-2-indolinone; tetrapropylammonium perruthennate; 4 A molecular sieve; TEA; In dichloromethane; toluene; xylene;

DOI:10.1021/jo034003g

upstream raw materials:

1-tosyloxy-1-vinylcyclopropane

3-(benzylamino)-2,2-dimethylpropan-1-ol

Downstream raw materials:

3-[benzyl(2-cyclopropylideneethyl)amino]-2,2-dimethylpropanal