(R)-3-(4-methoxyphenyl)-3-phenyl-2,3-dihydrobenzo[d]isothiazole 1,1-dioxide

Base Information

Chemical Name:(R)-3-(4-methoxyphenyl)-3-phenyl-2,3-dihydrobenzo[d]isothiazole 1,1-dioxide
CAS No.:1365284-12-3
Molecular Formula:C₂₀H₁₇NO₃S
Molecular Weight:351.426
Hs Code.:

Synonyms:(R)-3-(4-methoxyphenyl)-3-phenyl-2,3-dihydrobenzo[d]isothiazole 1,1-dioxide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-3-(4-methoxyphenyl)-3-phenyl-2,3-dihydrobenzo[d]isothiazole 1,1-dioxide

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Technology Process of (R)-3-(4-methoxyphenyl)-3-phenyl-2,3-dihydrobenzo[d]isothiazole 1,1-dioxide

There total 4 articles about (R)-3-(4-methoxyphenyl)-3-phenyl-2,3-dihydrobenzo[d]isothiazole 1,1-dioxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 53440-57-6
3-phenylbenzo[d]isothiazole-1,1-dioxide

: 7294-51-1
2,4,6-tris(4-methoxyphenyl)boroxine

: 1365284-12-3
(R)-3-(4-methoxyphenyl)-3-phenyl-2,3-dihydrobenzo[d]isothiazole 1,1-dioxide

Guidance literature:: With potassium phosphate; tert-Amyl alcohol; 2C₂₅H₃₄O₂*2ClRh; In 1,4-dioxane; at 60 ℃; for 12h; optical yield given as %ee; enantioselective reaction; Inert atmosphere;
DOI:10.1021/ja300697c

Reference yield: 93.0%

: 53440-57-6
3-phenylbenzo[d]isothiazole-1,1-dioxide

: 5720-05-8
4-methylphenylboronic acid

: 1365284-12-3
(R)-3-(4-methoxyphenyl)-3-phenyl-2,3-dihydrobenzo[d]isothiazole 1,1-dioxide

Guidance literature:: With palladium(II) trifluoroacetate; (S)-methyl 6-(4-(tert-butyl)-4,5-dihydrooxazol-2-yl)nicotinate; oxygen; In 2,2,2-trifluoroethanol; at 40 ℃; for 18h; enantioselective reaction;
DOI:10.1002/anie.201302861