trans-4-(4-{3-[-1-(2-chloro-3-fluoro-6-methoxyphenyl)-2-fluoroethyl]-1H-pyrrolo[2,3-b]pyridin-5-yl}-1H-pyrazol-1-yl)cyclohexanol

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Chemical Name:trans-4-(4-{3-[-1-(2-chloro-3-fluoro-6-methoxyphenyl)-2-fluoroethyl]-1H-pyrrolo[2,3-b]pyridin-5-yl}-1H-pyrazol-1-yl)cyclohexanol
CAS No.:1413875-80-5
Molecular Formula:C₂₅H₂₅ClF₂N₄O₂
Molecular Weight:486.949
Hs Code.:

Synonyms:trans-4-(4-{3-[-1-(2-chloro-3-fluoro-6-methoxyphenyl)-2-fluoroethyl]-1H-pyrrolo[2,3-b]pyridin-5-yl}-1H-pyrazol-1-yl)cyclohexanol

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Chemical Property of trans-4-(4-{3-[-1-(2-chloro-3-fluoro-6-methoxyphenyl)-2-fluoroethyl]-1H-pyrrolo[2,3-b]pyridin-5-yl}-1H-pyrazol-1-yl)cyclohexanol

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Technology Process of trans-4-(4-{3-[-1-(2-chloro-3-fluoro-6-methoxyphenyl)-2-fluoroethyl]-1H-pyrrolo[2,3-b]pyridin-5-yl}-1H-pyrazol-1-yl)cyclohexanol

There total 14 articles about trans-4-(4-{3-[-1-(2-chloro-3-fluoro-6-methoxyphenyl)-2-fluoroethyl]-1H-pyrrolo[2,3-b]pyridin-5-yl}-1H-pyrazol-1-yl)cyclohexanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1413876-13-7
C₃₁H₃₉ClF₂N₄O₂Si

: 1413875-80-5
trans-4-(4-{3-[-1-(2-chloro-3-fluoro-6-methoxyphenyl)-2-fluoroethyl]-1H-pyrrolo[2,3-b]pyridin-5-yl}-1H-pyrazol-1-yl)cyclohexanol

Guidance literature:: With hydrogenchloride; In tetrahydrofuran; water; at 0 - 20 ℃; for 0.5h;

Reference yield:

: 261762-39-4
2-chloro-3,6-difluorobenzaldehyde

: 1413875-80-5
trans-4-(4-{3-[-1-(2-chloro-3-fluoro-6-methoxyphenyl)-2-fluoroethyl]-1H-pyrrolo[2,3-b]pyridin-5-yl}-1H-pyrazol-1-yl)cyclohexanol

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium methylate / tetrahydrofuran; methanol / 60 °C

2.1: potassium hydroxide / methanol / 12 h / 20 °C

3.1: n-butyllithium / hexane; tetrahydrofuran / 0.5 h / -78 °C

3.2: 1.5 h / -78 - 20 °C

4.1: potassium fluoride / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 1.5 h / 90 °C / Inert atmosphere

5.1: disodium hydrogenphosphate; sodium amalgam; methanol / 1.5 h / -20 - -5 °C

6.1: hydrogenchloride / water; tetrahydrofuran / 0.5 h / 0 - 20 °C

With hydrogenchloride; methanol; potassium fluoride; disodium hydrogenphosphate; sodium amalgam; n-butyllithium; sodium methylate; potassium hydroxide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; 1,4-dioxane; methanol; hexane; water;

Reference yield:

: 183208-35-7
5-bromo-1H-pyrrolo[2,3-b]pyridine

: 1413875-80-5
trans-4-(4-{3-[-1-(2-chloro-3-fluoro-6-methoxyphenyl)-2-fluoroethyl]-1H-pyrrolo[2,3-b]pyridin-5-yl}-1H-pyrazol-1-yl)cyclohexanol

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium hydroxide / methanol / 12 h / 20 °C

2.1: n-butyllithium / hexane; tetrahydrofuran / 0.5 h / -78 °C

2.2: 1.5 h / -78 - 20 °C

3.1: potassium fluoride / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 1.5 h / 90 °C / Inert atmosphere

4.1: disodium hydrogenphosphate; sodium amalgam; methanol / 1.5 h / -20 - -5 °C

5.1: hydrogenchloride / water; tetrahydrofuran / 0.5 h / 0 - 20 °C

With hydrogenchloride; methanol; potassium fluoride; disodium hydrogenphosphate; sodium amalgam; n-butyllithium; potassium hydroxide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; 1,4-dioxane; methanol; hexane; water;