tert-butyl 4-fluoro-4-{3-[3-(pyrazin-2-ylamino)-1H-indazol-1-yl]phenyl}piperidine-1-carboxylate

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Chemical Name:tert-butyl 4-fluoro-4-{3-[3-(pyrazin-2-ylamino)-1H-indazol-1-yl]phenyl}piperidine-1-carboxylate
CAS No.:1394066-77-3
Molecular Formula:C₂₇H₂₉FN₆O₂
Molecular Weight:488.565
Hs Code.:

Synonyms:tert-butyl 4-fluoro-4-{3-[3-(pyrazin-2-ylamino)-1H-indazol-1-yl]phenyl}piperidine-1-carboxylate

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Chemical Property of tert-butyl 4-fluoro-4-{3-[3-(pyrazin-2-ylamino)-1H-indazol-1-yl]phenyl}piperidine-1-carboxylate

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Technology Process of tert-butyl 4-fluoro-4-{3-[3-(pyrazin-2-ylamino)-1H-indazol-1-yl]phenyl}piperidine-1-carboxylate

There total 5 articles about tert-butyl 4-fluoro-4-{3-[3-(pyrazin-2-ylamino)-1H-indazol-1-yl]phenyl}piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 14508-49-7
2-chloropyrazin

: 1394066-72-8
tert-butyl 4-[3-(3-amino-1H-indazol-1-yl)phenyl]-4-fluoropiperidine-1-carboxylate

: 1394066-77-3
tert-butyl 4-fluoro-4-{3-[3-(pyrazin-2-ylamino)-1H-indazol-1-yl]phenyl}piperidine-1-carboxylate

Guidance literature:: With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In toluene; at 100 ℃; for 16h; Inert atmosphere;

Reference yield:

: 79099-07-3
N-tert-butyloxycarbonylpiperidin-4-one

: 1394066-77-3
tert-butyl 4-fluoro-4-{3-[3-(pyrazin-2-ylamino)-1H-indazol-1-yl]phenyl}piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: tetrahydrofuran / 0 - 20 °C / Inert atmosphere

2: diethylamino-sulfur trifluoride / dichloromethane / 2 h / -78 °C / Inert atmosphere

3: potassium carbonate; copper(l) iodide; (1S,2S)-N,N'-dimethyl-1,2-diaminocyclohexane / 1-methyl-pyrrolidin-2-one / 16 h / 120 °C / Inert atmosphere

4: caesium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / 16 h / 100 °C / Inert atmosphere

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; copper(l) iodide; diethylamino-sulfur trifluoride; potassium carbonate; (1S,2S)-N,N'-dimethyl-1,2-diaminocyclohexane; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; dichloromethane; toluene;

Reference yield:

: 36229-42-2
(3-chlorophenyl)magnesium bromide

: 1394066-77-3
tert-butyl 4-fluoro-4-{3-[3-(pyrazin-2-ylamino)-1H-indazol-1-yl]phenyl}piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: tetrahydrofuran / 0 - 20 °C / Inert atmosphere

2: diethylamino-sulfur trifluoride / dichloromethane / 2 h / -78 °C / Inert atmosphere

3: potassium carbonate; copper(l) iodide; (1S,2S)-N,N'-dimethyl-1,2-diaminocyclohexane / 1-methyl-pyrrolidin-2-one / 16 h / 120 °C / Inert atmosphere

4: caesium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / 16 h / 100 °C / Inert atmosphere

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; copper(l) iodide; diethylamino-sulfur trifluoride; potassium carbonate; (1S,2S)-N,N'-dimethyl-1,2-diaminocyclohexane; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; dichloromethane; toluene;