Fmoc-Val-ala-PAB

Base Information

Chemical Name:Fmoc-Val-ala-PAB
CAS No.:1394238-91-5
Molecular Formula:C₃₀H₃₃N₃O₅
Molecular Weight:515.609
Hs Code.:
Mol file:1394238-91-5.mol

Synonyms:(9H-fluoren-9-yl)methyl ((S)-1-(((S)-1-((4-(hydroxymethyl)phenyl)amino)- 1-oxopropan-2-yl)amino)-3-methyl-1-oxobutan-2-yl)carbamate

Suppliers and Price of Fmoc-Val-ala-PAB

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Fmoc-Val-Ala-PAB
250mg
$ 305.00

TRC
Fmoc-Val-Ala-PAB
100mg
$ 155.00

TCI Chemical
Fmoc-Val-Ala-PAB-OH
250MG
$ 264.00

Iris Biotech GmbH
Fmoc-Val-Ala-PAB
1 g
$ 877.50

Iris Biotech GmbH
Fmoc-Val-Ala-PAB
250 mg
$ 303.75

DC Chemicals
Fmoc-Val-Ala-PAB-OH
001
$ 300.00

ChemScene
Fmoc-Val-Ala-PAB-OH
100mg
$ 508.00

Ambeed
(9H-Fluoren-9-yl)methyl((S)-1-(((S)-1-((4-(hydroxymethyl)phenyl)amino)-1-oxopropan-2-yl)amino)-3-methyl-1-oxobutan-2-yl)carbamate 98+%
100mg
$ 274.00

Ambeed
(9H-Fluoren-9-yl)methyl((S)-1-(((S)-1-((4-(hydroxymethyl)phenyl)amino)-1-oxopropan-2-yl)amino)-3-methyl-1-oxobutan-2-yl)carbamate 98+%
50mg
$ 162.00

Ambeed
(9H-Fluoren-9-yl)methyl((S)-1-(((S)-1-((4-(hydroxymethyl)phenyl)amino)-1-oxopropan-2-yl)amino)-3-methyl-1-oxobutan-2-yl)carbamate 98+%
25mg
$ 95.00

Total 18 raw suppliers

Chemical Property of Fmoc-Val-ala-PAB

Chemical Property:

Melting Point:218 °C(dec.)

Purity/Quality:

99%, ^*data from raw suppliers

Fmoc-Val-Ala-PAB ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Description Fmoc-Val-Ala-PAB is a cleavable ADC linker. The Val-Ala is effectively cleaved by lysosomal proteolytic enzymes while being highly stable in human plasma, making this a potentent stragy in ADC linker design. The Fmoc group can be deprotected under basic condition to obtain the free amine which can be used for further conjugations.
Uses Fmoc-Val-Ala-PAB is a building block used in the synthesis of RGD peptidomimetic-paclitaxel conjugates bearing lysosomally cleavable linkers.

Technology Process of Fmoc-Val-ala-PAB

There total 8 articles about Fmoc-Val-ala-PAB which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 150114-97-9
N-(9-fluorenylmethoxycarbonyl)-L-valyl-L-alanine

: 623-04-1
4-aminobenzenemethanol

: 1394238-91-5
(9H-fluoren-9-yl)methyl ((S)-1-(((S)-1-((4-(hydroxymethyl)phenyl)amino)- 1-oxopropan-2-yl)amino)-3-methyl-1-oxobutan-2-yl)carbamate

Guidance literature:: With N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; In methanol; dichloromethane; at 20 ℃; for 26h;

Reference yield: 74.59%

: 607383-80-2
(S)-2-amino-N-(4-(hydroxymethyl)phenyl)propionamide

: 68858-20-8
Fmoc-Val-OH

: 1394238-91-5
(9H-fluoren-9-yl)methyl ((S)-1-(((S)-1-((4-(hydroxymethyl)phenyl)amino)- 1-oxopropan-2-yl)amino)-3-methyl-1-oxobutan-2-yl)carbamate

Guidance literature:: With dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide; at 20 ℃; for 2h;

Reference yield:

: 68858-20-8
Fmoc-Val-OH

: 1394238-91-5
(9H-fluoren-9-yl)methyl ((S)-1-(((S)-1-((4-(hydroxymethyl)phenyl)amino)- 1-oxopropan-2-yl)amino)-3-methyl-1-oxobutan-2-yl)carbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: dicyclohexyl-carbodiimide; 1-hydroxy-pyrrolidine-2,5-dione / tetrahydrofuran / 16 h / 20 °C

1.2: 16 h / 20 °C

2.1: N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline / dichloromethane; methanol / 36 h / 20 °C

With 1-hydroxy-pyrrolidine-2,5-dione; N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; dicyclohexyl-carbodiimide; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.3390/ijms18091860