(11R,14S)-11-(3-Iodo-4-methoxy-phenyl)-9,12-dioxo-4-(pyrrolidin-1-ylazo)-2-oxa-10,13-diaza-tricyclo[14.2.2.1^3,7]henicosa-1⁽¹⁹⁾,3,5,7⁽²¹⁾,16⁽²⁰⁾,17-hexaene-14-carboxylic acid methyl ester

Base Information

• Chemical Name: (11R,14S)-11-(3-Iodo-4-methoxy-phenyl)-9,12-dioxo-4-(pyrrolidin-1-ylazo)-2-oxa-10,13-diaza-tricyclo[14.2.2.1^3,7]henicosa-1⁽¹⁹⁾,3,5,7⁽²¹⁾,16⁽²⁰⁾,17-hexaene-14-carboxylic acid methyl ester
• CAS No.: 197723-38-9
• Molecular Formula: C₃₁H₃₂IN₅O₆
• Molecular Weight: 697.529

Synonyms:(11R,14S)-11-(3-Iodo-4-methoxy-phenyl)-9,12-dioxo-4-(pyrrolidin-1-ylazo)-2-oxa-10,13-diaza-tricyclo[14.2.2.1^3,7]henicosa-1⁽¹⁹⁾,3,5,7⁽²¹⁾,16⁽²⁰⁾,17-hexaene-14-carboxylic acid methyl ester

Chemical Property of (11R,14S)-11-(3-Iodo-4-methoxy-phenyl)-9,12-dioxo-4-(pyrrolidin-1-ylazo)-2-oxa-10,13-diaza-tricyclo[14.2.2.1^3,7]henicosa-1⁽¹⁹⁾,3,5,7⁽²¹⁾,16⁽²⁰⁾,17-hexaene-14-carboxylic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (11R,14S)-11-(3-Iodo-4-methoxy-phenyl)-9,12-dioxo-4-(pyrrolidin-1-ylazo)-2-oxa-10,13-diaza-tricyclo[14.2.2.1^3,7]henicosa-1⁽¹⁹⁾,3,5,7⁽²¹⁾,16⁽²⁰⁾,17-hexaene-14-carboxylic acid methyl ester

There total 12 articles about (11R,14S)-11-(3-Iodo-4-methoxy-phenyl)-9,12-dioxo-4-(pyrrolidin-1-ylazo)-2-oxa-10,13-diaza-tricyclo[14.2.2.1^3,7]henicosa-1⁽¹⁹⁾,3,5,7⁽²¹⁾,16⁽²⁰⁾,17-hexaene-14-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

(S)-2-[(R)-2-{2-[3-Bromo-4-(pyrrolidin-1-ylazo)-phenyl]-acetylamino}-2-(3-iodo-4-methoxy-phenyl)-acetylamino]-3-(4-hydroxy-phenyl)-propionic acid methyl ester (197723-36-7) → (11S,14S)-11-(3-Iodo-4-methoxy-phenyl)-9,12-dioxo-4-(pyrrolidin-1-ylazo)-2-oxa-10,13-diaza-tricyclo[14.2.2.13,7]henicosa-1(19),3,5,7(21),16(20),17-hexaene-14-carboxylic acid methyl ester + (11R,14S)-11-(3-Iodo-4-methoxy-phenyl)-9,12-dioxo-4-(pyrrolidin-1-ylazo)-2-oxa-10,13-diaza-tricyclo[14.2.2.13,7]henicosa-1(19),3,5,7(21),16(20),17-hexaene-14-carboxylic acid methyl ester (197723-38-9)

Guidance literature:

With pyridine; copper(I) bromide dimethylsulfide complex; potassium carbonate; In acetonitrile; for 36h; Heating;

Reference yield: 67.0%

(S)-2-[(R)-2-{2-[3-Bromo-4-(pyrrolidin-1-ylazo)-phenyl]-acetylamino}-2-(3-iodo-4-methoxy-phenyl)-acetylamino]-3-(4-hydroxy-phenyl)-propionic acid methyl ester (250160-64-6) → (11S,14S)-11-(3-Iodo-4-methoxy-phenyl)-9,12-dioxo-4-(pyrrolidin-1-ylazo)-2-oxa-10,13-diaza-tricyclo[14.2.2.13,7]henicosa-1(19),3,5,7(21),16(20),17-hexaene-14-carboxylic acid methyl ester + (11R,14S)-11-(3-Iodo-4-methoxy-phenyl)-9,12-dioxo-4-(pyrrolidin-1-ylazo)-2-oxa-10,13-diaza-tricyclo[14.2.2.13,7]henicosa-1(19),3,5,7(21),16(20),17-hexaene-14-carboxylic acid methyl ester (197723-38-9)

Guidance literature:

With pyridine; copper(I) bromide dimethylsulfide complex; potassium carbonate; In acetonitrile; for 36h; Heating;

DOI:10.1002/(SICI)1521-3765(19990903)5:9<2584::AID-CHEM2584>3.0.CO;2-B

Reference yield:

2-(4-amino-3-bromophenyl)ethan-1-ol (169883-33-4) → (11R,14S)-11-(3-Iodo-4-methoxy-phenyl)-9,12-dioxo-4-(pyrrolidin-1-ylazo)-2-oxa-10,13-diaza-tricyclo[14.2.2.13,7]henicosa-1(19),3,5,7(21),16(20),17-hexaene-14-carboxylic acid methyl ester (197723-38-9)

Guidance literature:

Multi-step reaction with 4 steps

1.1: NaNO₂; HCl; H₂O / 0.5 h / 0 °C

1.2: 83 percent / K₂CO₃ / H₂O / 1 h / 0 °C

2.1: 86 percent / TEMPO; NaOCl; KBr / aq. NaHCO₃; acetone / 1 h / 0 °C

3.1: 90 percent / Et₃N; HBTU / dimethylformamide / 3 h / 0 - 25 °C

4.1: 67 percent / CuBr*Me₂S; K₂CO₃; pyridine / acetonitrile / 36 h / Heating

With pyridine; hydrogenchloride; 2,2,6,6-tetramethyl-piperidine-N-oxyl; sodium hypochlorite; copper(I) bromide dimethylsulfide complex; water; potassium carbonate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; potassium bromide; sodium nitrite; In sodium hydrogencarbonate; N,N-dimethyl-formamide; acetone; acetonitrile; 1.1: Diazotization / 1.2: Substitution / 2.1: Oxidation / 3.1: Acylation / 4.1: Cyclization;

DOI:10.1002/(SICI)1521-3765(19990903)5:9<2584::AID-CHEM2584>3.0.CO;2-B

upstream raw materials:

(S)-2-[(R)-2-{2-[3-Bromo-4-(pyrrolidin-1-ylazo)-phenyl]-acetylamino}-2-(3-iodo-4-methoxy-phenyl)-acetylamino]-3-(4-hydroxy-phenyl)-propionic acid methyl ester

(S)-2-[(R)-2-{2-[3-Bromo-4-(pyrrolidin-1-ylazo)-phenyl]-acetylamino}-2-(3-iodo-4-methoxy-phenyl)-acetylamino]-3-(4-hydroxy-phenyl)-propionic acid methyl ester

(R)-tert-Butoxycarbonylamino-(3-iodo-4-methoxy-phenyl)-acetic acid

2-(4-amino-3-bromophenyl)ethan-1-ol

Downstream raw materials:

(11R,14S)-11-(3-Iodo-4-methoxy-phenyl)-9,12-dioxo-2-oxa-10,13-diaza-tricyclo[14.2.2.1^3,7]henicosa-1⁽¹⁹⁾,3,5,7⁽²¹⁾,16⁽²⁰⁾,17-hexaene-14-carboxylic acid methyl ester

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 197723-38-9 (11R,14S)-11-(3-Iodo-4-methoxy-phenyl)-9,12-dioxo-4-(pyrrolidin-1-ylazo)-2-oxa-10,13-diaza-tricyclo[14.2.2.1^3,7]henicosa-1⁽¹⁹⁾,3,5,7⁽²¹⁾,16⁽²⁰⁾,17-hexaene-14-carboxylic acid methyl ester

Send

Send

Metric Ton KG G Pound L ML

Send

Send