5-Chloro-N-[(2R)-3-{[2-fluoro-4-(3-oxomorpholin-4-yl)phenyl]amino}-2-hydroxypropyl]thiophene-2-carboxamide

Base Information

• Chemical Name: 5-Chloro-N-[(2R)-3-{[2-fluoro-4-(3-oxomorpholin-4-yl)phenyl]amino}-2-hydroxypropyl]thiophene-2-carboxamide
• CAS No.: 1093628-70-6
• Molecular Formula: C₁₈H₁₉ClFN₃O₄S
• Molecular Weight: 427.884
• Mol file: 1093628-70-6.mol

Synonyms:5-Chloro-N-[(2R)-3-{[2-fluoro-4-(3-oxomorpholin-4-yl)phenyl]amino}-2-hydroxypropyl]thiophene-2-carboxamide

Chemical Property of 5-Chloro-N-[(2R)-3-{[2-fluoro-4-(3-oxomorpholin-4-yl)phenyl]amino}-2-hydroxypropyl]thiophene-2-carboxamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-Chloro-N-[(2R)-3-{[2-fluoro-4-(3-oxomorpholin-4-yl)phenyl]amino}-2-hydroxypropyl]thiophene-2-carboxamide

There total 8 articles about 5-Chloro-N-[(2R)-3-{[2-fluoro-4-(3-oxomorpholin-4-yl)phenyl]amino}-2-hydroxypropyl]thiophene-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

5-chloro-N-{[(2S)-oxiran-2-yl]methyl}thiophene-2-carboxamide (799012-78-5) + 4-(4-amino-3-fluoro-phenyl)-morpholin-3-one (742073-22-9) → 5-Chloro-N-[(2R)-3-{[2-fluoro-4-(3-oxomorpholin-4-yl)phenyl]amino}-2-hydroxypropyl]thiophene-2-carboxamide (1093628-70-6)

Guidance literature:

With magnesium(II) perchlorate; In acetonitrile; at 20 ℃; for 15h;

Reference yield:

2-fluro-4-iodoaniline (29632-74-4) → 5-Chloro-N-[(2R)-3-{[2-fluoro-4-(3-oxomorpholin-4-yl)phenyl]amino}-2-hydroxypropyl]thiophene-2-carboxamide (1093628-70-6)

Guidance literature:

Multi-step reaction with 4 steps

1: tetra-(n-butyl)ammonium iodide; sodium carbonate / dichloromethane; water / 144 h / Reflux

2: potassium phosphate; copper(l) iodide; N,N`-dimethylethylenediamine / 1,4-dioxane / 15 h / Inert atmosphere; Reflux

3: hydrogen / palladium 10% on activated carbon / ethanol / 1 h / 20 °C / 750.08 Torr

4: magnesium(II) perchlorate / acetonitrile / 15 h / 20 °C

With potassium phosphate; copper(l) iodide; magnesium(II) perchlorate; hydrogen; tetra-(n-butyl)ammonium iodide; sodium carbonate; N,N`-dimethylethylenediamine; palladium 10% on activated carbon; In 1,4-dioxane; ethanol; dichloromethane; water; acetonitrile;

Reference yield:

N,N-Dibenzyl-2-fluoro-4-iodoaniline (1093628-67-1) → 5-Chloro-N-[(2R)-3-{[2-fluoro-4-(3-oxomorpholin-4-yl)phenyl]amino}-2-hydroxypropyl]thiophene-2-carboxamide (1093628-70-6)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium phosphate; copper(l) iodide; N,N`-dimethylethylenediamine / 1,4-dioxane / 15 h / Inert atmosphere; Reflux

2: hydrogen / palladium 10% on activated carbon / ethanol / 1 h / 20 °C / 750.08 Torr

3: magnesium(II) perchlorate / acetonitrile / 15 h / 20 °C

With potassium phosphate; copper(l) iodide; magnesium(II) perchlorate; hydrogen; N,N`-dimethylethylenediamine; palladium 10% on activated carbon; In 1,4-dioxane; ethanol; acetonitrile;

upstream raw materials:

5-chloro-N-{[(2S)-oxiran-2-yl]methyl}thiophene-2-carboxamide

4-(4-amino-3-fluoro-phenyl)-morpholin-3-one

2-fluro-4-iodoaniline

5-chlorothiophene-2-carbonyl chloride

Downstream raw materials:

5-chloro-N-({(5S)-3-[2-fluoro-4-(3-oxomorpholin-4-yl)phenyl]-2-oxo-1,3-oxazolidin-5-yl}methyl)thiophene-2-carboxamide

N-(4-Aminobutanoyl)-5-chloro-N-({(5S)-2-oxo-3-[2-fluoro-4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl}methyl)thiophene-2-carboxamide hydrochloride

C₃₉H₃₈ClFN₄O₉S

5-chloro-N-[4-(methylamino)butanoyl]-N-({(5S)-2-oxo-3-[2-fluoro-4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl}methyl)thiophene-2-carboxamide hydrochloride