(R,R)-1,8-bis[3-[3-(3,4-dimethoxyphenyl)-1-hydroxypropyl]phenoxy]-3,6-dioxaoctane

Base Information

Chemical Name:(R,R)-1,8-bis[3-[3-(3,4-dimethoxyphenyl)-1-hydroxypropyl]phenoxy]-3,6-dioxaoctane
CAS No.:215168-97-1
Molecular Formula:C₄₀H₅₀O₁₀
Molecular Weight:690.831
Hs Code.:

Synonyms:(R,R)-1,8-bis[3-[3-(3,4-dimethoxyphenyl)-1-hydroxypropyl]phenoxy]-3,6-dioxaoctane

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Chemical Property of (R,R)-1,8-bis[3-[3-(3,4-dimethoxyphenyl)-1-hydroxypropyl]phenoxy]-3,6-dioxaoctane

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Technology Process of (R,R)-1,8-bis[3-[3-(3,4-dimethoxyphenyl)-1-hydroxypropyl]phenoxy]-3,6-dioxaoctane

There total 6 articles about (R,R)-1,8-bis[3-[3-(3,4-dimethoxyphenyl)-1-hydroxypropyl]phenoxy]-3,6-dioxaoctane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

: 215168-96-0
3-(3,4-dimethoxy-phenyl)-1-(3-{2-[2-(2-{3-[3-(3,4-dimethoxy-phenyl)-propionyl]-phenoxy}-ethoxy)-ethoxy]-ethoxy}-phenyl)-propan-1-one

: 215168-97-1
(R,R)-1,8-bis[3-[3-(3,4-dimethoxyphenyl)-1-hydroxypropyl]phenoxy]-3,6-dioxaoctane

Guidance literature:: With B-chlorodiisopinocampheylborane; In tetrahydrofuran; at -20 ℃;
DOI:10.1016/S0968-0896(98)00125-4

Reference yield:

: 121-71-1
3-Hydroxyacetophenone

: 215168-97-1
(R,R)-1,8-bis[3-[3-(3,4-dimethoxyphenyl)-1-hydroxypropyl]phenoxy]-3,6-dioxaoctane

Guidance literature:: Multi-step reaction with 4 steps

1: 91 percent / aq. KOH / ethanol / 16 h / 20 °C

2: 76 percent / H₂ / Lindlar catalyst / aq. methanol / 6 h / 2068.59 - 2585.74 Torr

3: 37 percent / NaH / dimethylformamide / 16 h / 20 °C

4: 43 percent / (+)-DIP-Chloride / tetrahydrofuran / -20 °C

With potassium hydroxide; hydrogen; sodium hydride; B-chlorodiisopinocampheylborane; Lindlar's catalyst; In tetrahydrofuran; methanol; ethanol; N,N-dimethyl-formamide; 1: Condensation / 2: Hydrogenation / 3: Alkylation / 4: Reduction;
DOI:10.1016/S0968-0896(98)00125-4

Reference yield:

: 120-14-9
3,4-dimethoxy-benzaldehyde

: 215168-97-1
(R,R)-1,8-bis[3-[3-(3,4-dimethoxyphenyl)-1-hydroxypropyl]phenoxy]-3,6-dioxaoctane

Guidance literature:: Multi-step reaction with 4 steps

1: 91 percent / aq. KOH / ethanol / 16 h / 20 °C

2: 76 percent / H₂ / Lindlar catalyst / aq. methanol / 6 h / 2068.59 - 2585.74 Torr

3: 37 percent / NaH / dimethylformamide / 16 h / 20 °C

4: 43 percent / (+)-DIP-Chloride / tetrahydrofuran / -20 °C

With potassium hydroxide; hydrogen; sodium hydride; B-chlorodiisopinocampheylborane; Lindlar's catalyst; In tetrahydrofuran; methanol; ethanol; N,N-dimethyl-formamide; 1: Condensation / 2: Hydrogenation / 3: Alkylation / 4: Reduction;
DOI:10.1016/S0968-0896(98)00125-4