ethyl 2-{2,6-dichloro-3-[(2,2-dimethyl-propionylamino)-methyl]-phenylamino}-6-(2,2-difluoro-ethoxy)-1-methyl-1H-benzimidazole-5-carboxylic acid ester

Base Information

Chemical Name:ethyl 2-{2,6-dichloro-3-[(2,2-dimethyl-propionylamino)-methyl]-phenylamino}-6-(2,2-difluoro-ethoxy)-1-methyl-1H-benzimidazole-5-carboxylic acid ester
CAS No.:1360624-40-3
Molecular Formula:C₂₅H₂₈Cl₂F₂N₄O₄
Molecular Weight:557.425
Hs Code.:

ethyl 2-{2,6-dichloro-3-[(2,2-dimethyl-propionylamino)-methyl]-phenylamino}-6-(2,2-difluoro-ethoxy)-1-methyl-1H-benzimidazole-5-carboxylic acid ester

Synonyms:ethyl 2-{2,6-dichloro-3-[(2,2-dimethyl-propionylamino)-methyl]-phenylamino}-6-(2,2-difluoro-ethoxy)-1-methyl-1H-benzimidazole-5-carboxylic acid ester

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Chemical Property of ethyl 2-{2,6-dichloro-3-[(2,2-dimethyl-propionylamino)-methyl]-phenylamino}-6-(2,2-difluoro-ethoxy)-1-methyl-1H-benzimidazole-5-carboxylic acid ester

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Technology Process of ethyl 2-{2,6-dichloro-3-[(2,2-dimethyl-propionylamino)-methyl]-phenylamino}-6-(2,2-difluoro-ethoxy)-1-methyl-1H-benzimidazole-5-carboxylic acid ester

There total 14 articles about ethyl 2-{2,6-dichloro-3-[(2,2-dimethyl-propionylamino)-methyl]-phenylamino}-6-(2,2-difluoro-ethoxy)-1-methyl-1H-benzimidazole-5-carboxylic acid ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 1242269-31-3
ethyl 5-amino-2-(2,2-difluoroethoxy)-4-(methylamino)benzoate

: 1360624-01-6
N-(2,4-dichloro-3-isothiocyanato-benzyl)-2,2-dimethyl-propionamide

: 1360624-40-3
ethyl 2-{2,6-dichloro-3-[(2,2-dimethyl-propionylamino)-methyl]-phenylamino}-6-(2,2-difluoro-ethoxy)-1-methyl-1H-benzimidazole-5-carboxylic acid ester

Guidance literature:: ethyl 5-amino-2-(2,2-difluoroethoxy)-4-(methylamino)benzoate; N-(2,4-dichloro-3-isothiocyanato-benzyl)-2,2-dimethyl-propionamide; In N,N-dimethyl-formamide; at 20 ℃;

With diisopropyl-carbodiimide; In N,N-dimethyl-formamide; at 80 ℃; for 6h;

Reference yield:

: C₂₅H₃₀Cl₂F₂N₄O₄S

: 1360624-40-3
ethyl 2-{2,6-dichloro-3-[(2,2-dimethyl-propionylamino)-methyl]-phenylamino}-6-(2,2-difluoro-ethoxy)-1-methyl-1H-benzimidazole-5-carboxylic acid ester

Guidance literature:: With diisopropyl-carbodiimide; In N,N-dimethyl-formamide; at 80 ℃; for 6h;

Reference yield:

: 1360624-03-8
N-(3-nitro-2,4-dichloro-benzyl)-2,2,2-trifluoroacetamide

: 1360624-40-3
ethyl 2-{2,6-dichloro-3-[(2,2-dimethyl-propionylamino)-methyl]-phenylamino}-6-(2,2-difluoro-ethoxy)-1-methyl-1H-benzimidazole-5-carboxylic acid ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydroxide; methanol / 4 h / Reflux

2.1: triethylamine / tetrahydrofuran

3.1: hydrogen / Ra-Ni / tetrahydrofuran / 7 h / 2585.81 Torr

4.1: 1,4-dioxane / 10 h / 20 °C / Reflux

5.1: N,N-dimethyl-formamide / 20 °C

5.2: 6 h / 80 °C

With methanol; hydrogen; triethylamine; sodium hydroxide; Ra-Ni; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl-formamide;