N-[(trans-4-{2-[(1R)-1-hydroxyethyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl}cyclohexyl)methyl]methanesulfonamide trifluoroacetate

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Chemical Name:N-[(trans-4-{2-[(1R)-1-hydroxyethyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl}cyclohexyl)methyl]methanesulfonamide trifluoroacetate
CAS No.:1607592-50-6
Molecular Formula:C₂HF₃O₂*C₁₈H₂₄N₄O₃S₂
Molecular Weight:522.57
Hs Code.:

Synonyms:N-[(trans-4-{2-[(1R)-1-hydroxyethyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl}cyclohexyl)methyl]methanesulfonamide trifluoroacetate

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Chemical Property of N-[(trans-4-{2-[(1R)-1-hydroxyethyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl}cyclohexyl)methyl]methanesulfonamide trifluoroacetate

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Technology Process of N-[(trans-4-{2-[(1R)-1-hydroxyethyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl}cyclohexyl)methyl]methanesulfonamide trifluoroacetate

There total 7 articles about N-[(trans-4-{2-[(1R)-1-hydroxyethyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl}cyclohexyl)methyl]methanesulfonamide trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 16.0%

: (1R)-1-{1-[trans-4-(aminomethyl)cyclohexyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-2-yl}ethanol bis(trifluoroacetate)

: 124-63-0
methanesulfonyl chloride

: 76-05-1
trifluoroacetic acid

: 1607592-50-6
N-[(trans-4-{2-[(1R)-1-hydroxyethyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl}cyclohexyl)methyl]methanesulfonamide trifluoroacetate

Guidance literature:: (1R)-1-{1-[trans-4-(aminomethyl)cyclohexyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-2-yl}ethanol bis(trifluoroacetate); methanesulfonyl chloride; With triethylamine; In dichloromethane; at 20 ℃; for 1h;

trifluoroacetic acid; In dichloromethane; water; acetonitrile;

Reference yield:

: 69627-02-7,107818-20-2
thieno[3,2-b]pyridin-7-ol

: 1607592-50-6
N-[(trans-4-{2-[(1R)-1-hydroxyethyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl}cyclohexyl)methyl]methanesulfonamide trifluoroacetate

Guidance literature:: Multi-step reaction with 7 steps

1.1: tetrabutylammonium nitrate / dichloromethane / -5 °C

1.2: -5 - 20 °C

2.1: trichlorophosphate / 1 h / Reflux

3.1: triethylamine / isopropyl alcohol / 2 h / 90 °C

4.1: hydrogen; palladium 10% on activated carbon / methanol / 2 h / 20 °C

5.1: triethyloxonium fluoroborate / tetrahydrofuran / 20 °C

5.2: 2 h / 85 °C

6.1: dichloromethane / 1 h / 20 °C

7.1: triethylamine / dichloromethane / 1 h / 20 °C

With palladium 10% on activated carbon; hydrogen; triethyloxonium fluoroborate; tetrabutylammonium nitrate; triethylamine; trichlorophosphate; In tetrahydrofuran; methanol; dichloromethane; isopropyl alcohol;

Reference yield:

: 110651-92-8
7-chloro-6-nitrothieno[3,2-b]pyridine

: 1607592-50-6
N-[(trans-4-{2-[(1R)-1-hydroxyethyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl}cyclohexyl)methyl]methanesulfonamide trifluoroacetate

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine / isopropyl alcohol / 2 h / 90 °C

2.1: hydrogen; palladium 10% on activated carbon / methanol / 2 h / 20 °C

3.1: triethyloxonium fluoroborate / tetrahydrofuran / 20 °C

3.2: 2 h / 85 °C

4.1: dichloromethane / 1 h / 20 °C

5.1: triethylamine / dichloromethane / 1 h / 20 °C

With palladium 10% on activated carbon; hydrogen; triethyloxonium fluoroborate; triethylamine; In tetrahydrofuran; methanol; dichloromethane; isopropyl alcohol;