methyl (S)-3-(4-benzyl-5-oxo-2-thioxo-2,3,4,5-tetrahydro-1H-1,4-benzodiazepin-3-yl)propanoate

Base Information

Chemical Name:methyl (S)-3-(4-benzyl-5-oxo-2-thioxo-2,3,4,5-tetrahydro-1H-1,4-benzodiazepin-3-yl)propanoate
CAS No.:1620751-44-1
Molecular Formula:C₂₀H₂₀N₂O₃S
Molecular Weight:368.456
Hs Code.:

Synonyms:methyl (S)-3-(4-benzyl-5-oxo-2-thioxo-2,3,4,5-tetrahydro-1H-1,4-benzodiazepin-3-yl)propanoate

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Chemical Property of methyl (S)-3-(4-benzyl-5-oxo-2-thioxo-2,3,4,5-tetrahydro-1H-1,4-benzodiazepin-3-yl)propanoate

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Technology Process of methyl (S)-3-(4-benzyl-5-oxo-2-thioxo-2,3,4,5-tetrahydro-1H-1,4-benzodiazepin-3-yl)propanoate

There total 6 articles about methyl (S)-3-(4-benzyl-5-oxo-2-thioxo-2,3,4,5-tetrahydro-1H-1,4-benzodiazepin-3-yl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 1620751-43-0
methyl (S)-3-(4-benzyl-2,5-dioxo-2,3,4,5-tetrahydro-1H-1,4-benzodiazepin-3-yl)propanoate

: 1620751-44-1
methyl (S)-3-(4-benzyl-5-oxo-2-thioxo-2,3,4,5-tetrahydro-1H-1,4-benzodiazepin-3-yl)propanoate

Guidance literature:: With Lawessons reagent; In tetrahydrofuran; at 75 ℃; for 1h;
DOI:10.1055/s-0033-1338558

Reference yield:

: 1620751-42-9
dimethyl (S)-2-(N-benzyl-2-nitrobenzamido)pentanedioate

: 1620751-44-1
methyl (S)-3-(4-benzyl-5-oxo-2-thioxo-2,3,4,5-tetrahydro-1H-1,4-benzodiazepin-3-yl)propanoate

Guidance literature:: Multi-step reaction with 3 steps

1: ammonium chloride; zinc / methanol / 0.17 h / 20 °C

2: zinc; toluene-4-sulfonic acid / 16 h / Reflux

3: Lawessons reagent / tetrahydrofuran / 1 h / 75 °C

With Lawessons reagent; ammonium chloride; toluene-4-sulfonic acid; zinc; In tetrahydrofuran; methanol;
DOI:10.1055/s-0033-1338558

Reference yield:

: 100-52-7
benzaldehyde

: 1620751-44-1
methyl (S)-3-(4-benzyl-5-oxo-2-thioxo-2,3,4,5-tetrahydro-1H-1,4-benzodiazepin-3-yl)propanoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine; sodium sulfate / methanol / 16 h / 0 - 20 °C

1.2: 0.5 h / 0 °C

2.1: potassium carbonate; tetra-(n-butyl)ammonium iodide / N,N-dimethyl acetamide / 4 h / 0 - 20 °C

3.1: ammonium chloride; zinc / methanol / 0.17 h / 20 °C

4.1: zinc; toluene-4-sulfonic acid / 16 h / Reflux

5.1: Lawessons reagent / tetrahydrofuran / 1 h / 75 °C

With Lawessons reagent; tetra-(n-butyl)ammonium iodide; potassium carbonate; ammonium chloride; toluene-4-sulfonic acid; sodium sulfate; triethylamine; zinc; In tetrahydrofuran; methanol; N,N-dimethyl acetamide;
DOI:10.1055/s-0033-1338558