6-butyl-5-(4-cyclohexyloxy-phenyl)-4-trifluoromethyl-2H-pyridazin-3-one

Base Information

Chemical Name:6-butyl-5-(4-cyclohexyloxy-phenyl)-4-trifluoromethyl-2H-pyridazin-3-one
CAS No.:1331776-45-4
Molecular Formula:C₂₁H₂₅F₃N₂O₂
Molecular Weight:394.437
Hs Code.:

Synonyms:6-butyl-5-(4-cyclohexyloxy-phenyl)-4-trifluoromethyl-2H-pyridazin-3-one

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Chemical Property of 6-butyl-5-(4-cyclohexyloxy-phenyl)-4-trifluoromethyl-2H-pyridazin-3-one

Chemical Property:

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Technology Process of 6-butyl-5-(4-cyclohexyloxy-phenyl)-4-trifluoromethyl-2H-pyridazin-3-one

There total 5 articles about 6-butyl-5-(4-cyclohexyloxy-phenyl)-4-trifluoromethyl-2H-pyridazin-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1331776-44-3
3-(4-cyclohexyloxyphenyl)-4-oxo-2-trifluoromethyl-oct-2-enoic acid methyl ester

: 1331776-45-4
6-butyl-5-(4-cyclohexyloxy-phenyl)-4-trifluoromethyl-2H-pyridazin-3-one

Guidance literature:: With hydrazine hydrate; acetic acid; at 100 ℃; for 12h;

Reference yield:

: 14199-15-6
Methyl 4-hydroxyphenylacetate

: 1331776-45-4
6-butyl-5-(4-cyclohexyloxy-phenyl)-4-trifluoromethyl-2H-pyridazin-3-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: di-isopropyl azodicarboxylate / triphenylphosphine / tetrahydrofuran / 0.83 h / Inert atmosphere

2.1: sodium hydroxide; water / tetrahydrofuran; methanol

3.1: oxalyl dichloride / dichloromethane / 12 h / 0 °C

3.2: 12 h / 0 °C

4.1: hexane; tetrahydrofuran / 0.75 h / -78 °C

5.1: triethylamine / tetrahydrofuran / 12 h / 20 °C

6.1: hydrazine hydrate; acetic acid / 12 h / 100 °C

With oxalyl dichloride; di-isopropyl azodicarboxylate; water; hydrazine hydrate; acetic acid; triethylamine; sodium hydroxide; triphenylphosphine; In tetrahydrofuran; methanol; hexane; dichloromethane;

Reference yield:

: 1046140-44-6
(4-cyclohexyloxyphenyl)acetic acid methyl ester

: 1331776-45-4
6-butyl-5-(4-cyclohexyloxy-phenyl)-4-trifluoromethyl-2H-pyridazin-3-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydroxide; water / tetrahydrofuran; methanol

2.1: oxalyl dichloride / dichloromethane / 12 h / 0 °C

2.2: 12 h / 0 °C

3.1: hexane; tetrahydrofuran / 0.75 h / -78 °C

4.1: triethylamine / tetrahydrofuran / 12 h / 20 °C

5.1: hydrazine hydrate; acetic acid / 12 h / 100 °C

With oxalyl dichloride; water; hydrazine hydrate; acetic acid; triethylamine; sodium hydroxide; In tetrahydrofuran; methanol; hexane; dichloromethane;