Technology Process of 4-[6-butyl-5-(4-cyclohexyloxyphenyl)-4-trifluoromethylpyridazin-3-yloxy]piperidine-1-carboxylic acid tert-butyl ester
There total 7 articles about 4-[6-butyl-5-(4-cyclohexyloxyphenyl)-4-trifluoromethylpyridazin-3-yloxy]piperidine-1-carboxylic acid tert-butyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
t-butyl 4-hydroxy piperidine-1-carboxylate;
With
sodium hydride;
In
N,N-dimethyl-formamide; mineral oil;
at 20 ℃;
for 0.166667h;
3-butyl-6-chloro-4-(4-cyclohexyloxyphenyl)-5-trifluoromethylpyridazine;
In
N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: di-isopropyl azodicarboxylate / triphenylphosphine / tetrahydrofuran / 0.83 h / Inert atmosphere
2.1: sodium hydroxide; water / tetrahydrofuran; methanol
3.1: oxalyl dichloride / dichloromethane / 12 h / 0 °C
3.2: 12 h / 0 °C
4.1: hexane; tetrahydrofuran / 0.75 h / -78 °C
5.1: triethylamine / tetrahydrofuran / 12 h / 20 °C
6.1: hydrazine hydrate; acetic acid / 12 h / 100 °C
7.1: trichlorophosphate / 1 h / 90 °C
8.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.17 h / 20 °C
With
oxalyl dichloride; di-isopropyl azodicarboxylate; water; sodium hydride; hydrazine hydrate; acetic acid; triethylamine; sodium hydroxide; trichlorophosphate;
triphenylphosphine;
In
tetrahydrofuran; methanol; hexane; dichloromethane; N,N-dimethyl-formamide; mineral oil;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: sodium hydroxide; water / tetrahydrofuran; methanol
2.1: oxalyl dichloride / dichloromethane / 12 h / 0 °C
2.2: 12 h / 0 °C
3.1: hexane; tetrahydrofuran / 0.75 h / -78 °C
4.1: triethylamine / tetrahydrofuran / 12 h / 20 °C
5.1: hydrazine hydrate; acetic acid / 12 h / 100 °C
6.1: trichlorophosphate / 1 h / 90 °C
7.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.17 h / 20 °C
With
oxalyl dichloride; water; sodium hydride; hydrazine hydrate; acetic acid; triethylamine; sodium hydroxide; trichlorophosphate;
In
tetrahydrofuran; methanol; hexane; dichloromethane; N,N-dimethyl-formamide; mineral oil;