2-Boc-amino-4-hydroxymethylpyridine

Base Information

• Chemical Name: 2-Boc-amino-4-hydroxymethylpyridine
• CAS No.: 304873-62-9
• Molecular Formula: C₁₁H₁₆N₂O₃
• Molecular Weight: 224.26
• Hs Code.: 2933399090
• Mol file: 304873-62-9.mol

Synonyms:Carbamicacid, [4-(hydroxymethyl)-2-pyridinyl]-, 1,1-dimethylethyl ester (9CI)

Chemical Property of 2-Boc-amino-4-hydroxymethylpyridine

Chemical Property:

• Vapor Pressure: 5.45E-05mmHg at 25°C
• Melting Point: 137-138 °C
• Refractive Index: 1.567
• Boiling Point: 333.4°Cat760mmHg
• PKA: 12.40±0.70(Predicted)
• Flash Point: 155.4°C
• PSA: 71.45000
• Density: 1.209g/cm³
• LogP: 1.99390
• Storage Temp.: 2-8°C

Purity/Quality:

99%, ^*data from raw suppliers

2-(Boc-amino)-4-(hydroxymethyl)pyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Boc-amino-4-hydroxymethylpyridine

There total 11 articles about 2-Boc-amino-4-hydroxymethylpyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.1%

methyl 2-[(tert-butoxycarbonyl)amino]isonicotinate (639091-75-1,470463-38-8) → (4-hydroxymethylpyridin-2-yl)carbamic acid tert-butyl ester (304873-62-9)

Guidance literature:

With sodium tetrahydroborate; calcium chloride; In ethanol; at 20 ℃; for 4h;

DOI:10.1016/j.bmc.2005.03.052

Reference yield: 90.0%

2-[N,N-mono-(tert-butoxycarbonyl)amino]-pyridyl-4-aldehyde (304873-65-2) → (4-hydroxymethylpyridin-2-yl)carbamic acid tert-butyl ester (304873-62-9)

Guidance literature:

With sodium tetrahydroborate; In tetrahydrofuran; methanol; at 0 - 25 ℃; for 12h;

Reference yield: 86.0%

2-[N,N-bis(tert-butoxycarbonyl)amino]isonicotinic acid ethyl ester (305329-03-7) → (4-hydroxymethylpyridin-2-yl)carbamic acid tert-butyl ester (304873-62-9)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; for 1h; Heating;

DOI:10.1016/j.bmc.2003.12.039

upstream raw materials:

methyl 2-[(tert-butoxycarbonyl)amino]isonicotinate

2-[N,N-bis(tert-butoxycarbonyl)amino]isonicotinic acid ethyl ester

tert-Butyl N-(4-methyl-pyridin-2-yl)carbamate

2-chloroisonicotinic acid,

Downstream raw materials:

2-[N,N-mono-(tert-butoxycarbonyl)amino]-pyridyl-4-aldehyde

(Z)-4-(4-fluorostyryl)-pyridin-2-amine

(Z)-tert-butyl 4-(4-fluorostyryl)pyridin-2-yl(isopropyl)carbamate

(Z)-4-(4-fluorostyryl)-N-isopropylpyridin-2-amine

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