(Z)-4-(4-fluorostyryl)-N-isopropylpyridin-2-amine

Base Information

Chemical Name:(Z)-4-(4-fluorostyryl)-N-isopropylpyridin-2-amine
CAS No.:1446252-30-7
Molecular Formula:C₁₆H₁₇FN₂
Molecular Weight:256.323
Hs Code.:

Synonyms:(Z)-4-(4-fluorostyryl)-N-isopropylpyridin-2-amine

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Chemical Property of (Z)-4-(4-fluorostyryl)-N-isopropylpyridin-2-amine

Chemical Property:

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Technology Process of (Z)-4-(4-fluorostyryl)-N-isopropylpyridin-2-amine

There total 5 articles about (Z)-4-(4-fluorostyryl)-N-isopropylpyridin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 1446252-29-4
(Z)-tert-butyl 4-(4-fluorostyryl)pyridin-2-yl(isopropyl)carbamate

: 1446252-30-7
(Z)-4-(4-fluorostyryl)-N-isopropylpyridin-2-amine

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 3h;
DOI:10.1039/c3ob27449g

Reference yield:

: 6937-03-7
methyl 2-aminoisonicotinate

: 1446252-30-7
(Z)-4-(4-fluorostyryl)-N-isopropylpyridin-2-amine

Guidance literature:: Multi-step reaction with 6 steps

1.1: dmap / tert-butyl alcohol; acetone / 15 h / 20 °C

2.1: sodium tetrahydroborate; calcium chloride / ethanol / 7 h / 20 °C

3.1: Dess-Martin periodane / dichloromethane / 15 h

4.1: lithium hydroxide monohydrate / isopropyl alcohol / 0.25 h / 20 °C

4.2: 1 h / 60 °C / Microwave irradiation

5.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C / Inert atmosphere

5.2: 4.5 h / 0 - 20 °C / Inert atmosphere

6.1: trifluoroacetic acid / dichloromethane / 3 h / 20 °C

With dmap; sodium tetrahydroborate; lithium hydroxide monohydrate; sodium hydride; Dess-Martin periodane; trifluoroacetic acid; calcium chloride; In ethanol; dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol; acetone; mineral oil; tert-butyl alcohol; 4.1: |Wittig Olefination / 4.2: |Wittig Olefination;
DOI:10.1039/c3ob27449g

Reference yield:

: 639091-75-1,470463-38-8
methyl 2-[(tert-butoxycarbonyl)amino]isonicotinate

: 1446252-30-7
(Z)-4-(4-fluorostyryl)-N-isopropylpyridin-2-amine

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium tetrahydroborate; calcium chloride / ethanol / 7 h / 20 °C

2.1: Dess-Martin periodane / dichloromethane / 15 h

3.1: lithium hydroxide monohydrate / isopropyl alcohol / 0.25 h / 20 °C

3.2: 1 h / 60 °C / Microwave irradiation

4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C / Inert atmosphere

4.2: 4.5 h / 0 - 20 °C / Inert atmosphere

5.1: trifluoroacetic acid / dichloromethane / 3 h / 20 °C

With sodium tetrahydroborate; lithium hydroxide monohydrate; sodium hydride; Dess-Martin periodane; trifluoroacetic acid; calcium chloride; In ethanol; dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol; mineral oil; 3.1: |Wittig Olefination / 3.2: |Wittig Olefination;
DOI:10.1039/c3ob27449g