(S)-N-(1-(8-chloro-1-oxo-2-phenyl-1,2-dihydroisoquinolin-3yl)ethyl)-2-cyanoacetamide

Base Information

Chemical Name:(S)-N-(1-(8-chloro-1-oxo-2-phenyl-1,2-dihydroisoquinolin-3yl)ethyl)-2-cyanoacetamide
CAS No.:1466565-67-2
Molecular Formula:C₂₀H₁₆ClN₃O₂
Molecular Weight:365.819
Hs Code.:

Synonyms:(S)-N-(1-(8-chloro-1-oxo-2-phenyl-1,2-dihydroisoquinolin-3yl)ethyl)-2-cyanoacetamide

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Chemical Property of (S)-N-(1-(8-chloro-1-oxo-2-phenyl-1,2-dihydroisoquinolin-3yl)ethyl)-2-cyanoacetamide

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Technology Process of (S)-N-(1-(8-chloro-1-oxo-2-phenyl-1,2-dihydroisoquinolin-3yl)ethyl)-2-cyanoacetamide

There total 5 articles about (S)-N-(1-(8-chloro-1-oxo-2-phenyl-1,2-dihydroisoquinolin-3yl)ethyl)-2-cyanoacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 16130-58-8
cyanoacetic acid chloride

: 1350643-72-9
(S)-3-(1-aminoethyl)-8-chloro-2-phenylisoquinoline-1(2H)-one

: 1466565-67-2
(S)-N-(1-(8-chloro-1-oxo-2-phenyl-1,2-dihydroisoquinolin-3yl)ethyl)-2-cyanoacetamide

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 23 ℃; for 2h;
DOI:10.1021/acsmedchemlett.6b00238

Reference yield:

: 21327-86-6
2-chloro-6-methylbenzoic acid

: 1466565-67-2
(S)-N-(1-(8-chloro-1-oxo-2-phenyl-1,2-dihydroisoquinolin-3yl)ethyl)-2-cyanoacetamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: oxalyl dichloride / N,N-dimethyl-formamide; dichloromethane / 2 h / 20 °C

1.2: 2 h / 25 - 40 °C / Cooling with ice

2.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -30 - -10 °C / Inert atmosphere

2.2: 2 h / -30 - -10 °C / Inert atmosphere

2.3: 10.5 h / 20 °C

3.1: triethylamine / dichloromethane / 2 h / 0 - 20 °C

With n-butyllithium; oxalyl dichloride; triethylamine; In tetrahydrofuran; hexane; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1386861-46-6
2-chloro-6-methyl-N-phenylbenzamide

: 1466565-67-2
(S)-N-(1-(8-chloro-1-oxo-2-phenyl-1,2-dihydroisoquinolin-3yl)ethyl)-2-cyanoacetamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -30 - -10 °C / Inert atmosphere

1.2: 2 h / -30 - -10 °C / Inert atmosphere

1.3: 10.5 h / 20 °C

2.1: triethylamine / dichloromethane / 2 h / 0 - 20 °C

With n-butyllithium; triethylamine; In tetrahydrofuran; hexane; dichloromethane;