6-BROMO-2,4,4-TRIMETHYL-2,4-DIHYDRO-1H-BENZO[D][1,3]OXAZINE

Base Information

• Chemical Name: 6-BROMO-2,4,4-TRIMETHYL-2,4-DIHYDRO-1H-BENZO[D][1,3]OXAZINE
• CAS No.: 304858-44-4
• Molecular Formula: C11H14 Br N O
• Molecular Weight: 256.142
• Hs Code.: 2934999090
• Mol file: 304858-44-4.mol

Synonyms:6-BROMO-2,4,4-TRIMETHYL-2,4-DIHYDRO-1H-BENZO[D][1,3]OXAZINE

Chemical Property of 6-BROMO-2,4,4-TRIMETHYL-2,4-DIHYDRO-1H-BENZO[D][1,3]OXAZINE

Chemical Property:

• Boiling Point: 326.9±42.0 °C(Predicted)
• PKA: 2.37±0.60(Predicted)
• PSA: 21.26000
• Density: 1.294±0.06 g/cm3(Predicted)
• LogP: 3.61030

Purity/Quality:

95% ^*data from raw suppliers

6-BROMO-2,4,4-TRIMETHYL-2,4-DIHYDRO-1H-BENZO[D][1,3]OXAZINE 98.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-BROMO-2,4,4-TRIMETHYL-2,4-DIHYDRO-1H-BENZO[D][1,3]OXAZINE

There total 3 articles about 6-BROMO-2,4,4-TRIMETHYL-2,4-DIHYDRO-1H-BENZO[D][1,3]OXAZINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

nitrogen acetylaldehyde + 2-(2-amino-5-bromophenyl)-propan-2-ol (304853-89-2) → 6-bromo-2,4,4-trimethyl-1,4-dihydro-2H-1,3-benzoxazine (304858-44-4)

Guidance literature:

In toluene;

Reference yield: 78.0%

acetaldehyde (75-07-0,9002-91-9) + 2-(2-amino-5-bromophenyl)-propan-2-ol (304853-89-2) → 6-bromo-2,4,4-trimethyl-1,4-dihydro-2H-1,3-benzoxazine (304858-44-4)

Guidance literature:

In toluene; at 20 ℃; for 0.166667h;

Reference yield:

1-(2-amino-5-bromophenyl)ethanone (29124-56-9) → 6-bromo-2,4,4-trimethyl-1,4-dihydro-2H-1,3-benzoxazine (304858-44-4)

Guidance literature:

Multi-step reaction with 2 steps

1: diethyl ether / 0 °C

2: p-TsOH / toluene / 20 °C

With toluene-4-sulfonic acid; In diethyl ether; toluene;

DOI:10.1016/S0960-894X(02)00025-2

upstream raw materials:

acetaldehyde

2-(2-amino-5-bromophenyl)-propan-2-ol

1-(2-amino-5-bromophenyl)ethanone

Downstream raw materials:

4-(2,4,4-Trimethyl-1,4-dihydro-2H-3,1-benzoxazin-6-yl)thiophene-2-carbonitrile