29124-56-9

Usage

Uses

Used in Organic Synthesis:
1-(2-amino-5-bromophenyl)ethanone is used as a key intermediate in organic synthesis for the production of various drugs. Its unique structure and functional groups make it a valuable component in the synthesis process.
Used in Pharmaceutical Research:
In pharmaceutical research, 1-(2-amino-5-bromophenyl)ethanone serves as a crucial building block for the development of new drugs. Its presence in the molecular structure can contribute to the desired pharmacological properties of the final drug product.
Used in the Production of Dyes:
1-(2-amino-5-bromophenyl)ethanone is used as a starting material in the production of dyes. Its chemical properties allow for the creation of dyes with specific color characteristics and stability.
Used in the Development of New Materials:
Due to its potential as a building block, 1-(2-amino-5-bromophenyl)ethanone has been explored for its use in the development of new materials. Its unique structure and functional groups can contribute to the creation of materials with novel properties and applications.
Used in Research Efforts:
1-(2-amino-5-bromophenyl)ethanone has been the subject of numerous studies and research efforts, aiming to explore its potential applications in various fields. Its unique structure and functional groups make it an interesting compound for further investigation and development.

Upstream product

• 551-93-9 2-aminoacetophenone 
• 29124-64-9 N-(2-acetyl-4-bromophenyl)acetamide 
• 617-35-6 2-oxo-propionic acid ethyl ester 
• 41877-24-1 1-(5-bromo-2-nitrophenyl)ethane-1-one 
• 75-05-8 acetonitrile 
• 106-40-1 4-bromo-aniline 
• 5234-26-4 N-(2-acetylphenyl)acetamide 
• 917-54-4 methyllithium 
• 5794-88-7 5-Bromo-2-aminobenzoic acid 
• 613-89-8 2-Aminoacetophenone 
• 304854-54-4 2-amino-5-bromo-N-methoxy-N-methyl-benzamide 
• 75-16-1 methylmagnesium bromide 
• 39263-32-6 2-amino-5-bromobenzonitrile 
• 676-58-4 methylmagnesium chloride 

Downstream Products

• 876-88-0 6-bromo-1H-cinnolin-4-one 
• 84-40-2 5,5'-dibromo-1H,1'H-[2,2']biindolylidene-3,3'-dione 
• 304853-89-2 2-(2-amino-5-bromophenyl)-propan-2-ol 
• 857550-48-2 1-(2-amino-5-bromo-phenyl)-1-phenyl-ethanol 
• 865670-66-2 1-(2-amino-5-bromophenyl)-1-thiophen-2-yl-ethanol 
• 1020576-91-3 ethyl 2-((2-acetyl-4-bromophenyl)amino)-2-oxoacetate 
• 937817-49-7 (2-acetyl-4-bromophenylamino)acetic acid ethyl ester 
• 946160-84-5 C₂₂H₁₈BrClN₂O₄S 
• 318276-72-1 6-bromocinnoline 
• 68211-15-4 6-bromo-4-chlorocinnoline 
• 304858-44-4 6-bromo-2,4,4-trimethyl-1,4-dihydro-2H-1,3-benzoxazine 
• 68211-13-2 4,6-dichlorocinnoline 
• 865670-82-2 1-(2-amino-5-bromophenyl)-1-(2-furyl)ethanol 
• 865670-86-6 1-(2-amino-5-bromophenyl)-1-thien-3-ylethanol 

Relevant academic research and scientific papers

In vitro cytotoxicity of novel 2,5,7-tricarbo-substituted indoles derived from 2-amino-5-bromo-3-iodoacetophenone

A series of novel 2,5,7-tricarbo-substituted indoles were prepared via sequential Sonogashira and Suzuki–Miyaura cross-coupling of 2-amino-5-bromo-3-iodoacetophenone with terminal acetylenes and aryl/styrylboronic acids followed by palladium chloride-medi

A facile access to novel heterocyclic analogues of chalcone from newly synthesized ketone containing isoxazole and a benzoxazinone ring

A series of novel heterocyclic analogs of chalcone containing isoxazole and a benzoxazinone ring as a prime motif was rationally designed and synthesized. There is nothing in the literature about such α,β-unsaturated ketones. These compounds were synthesi

Discovery of Chromane-6-Sulfonamide Derivative as a Potent, Selective, and Orally Available Novel Retinoic Acid Receptor-Related Orphan Receptor γt Inverse Agonist

Interleukin-17 (IL-17) is a proinflammatory cytokine that plays a dominant role in inflammation, autoimmunity, and host defense. RORγt is a key transcription factor mediating T helper 17 (Th17) cell differentiation and IL-17 production, which is able to activate CD8+ T cells and elicit antitumor efficacy. A series of sulfonamide derivatives as novel RORγt inverse agonists were designed and synthesized. Using GSK2981278 (phase II) as a starting point, we engineered structural modifications that significantly improved the activity and pharmacokinetic profile. In animal studies, oral administration of compound d3 showed a robust and dose-dependent inhibition of the IL-17A cytokine expression in a mouse imiquimod-induced skin inflammation model. Docking analysis of the binding mode revealed that the compound d3 occupied the active pocket suitably. Thus, compound d3 was selected as a clinical compound for the treatment of Th17-driven autoimmune diseases.

Discovery of cinnoline derivatives as potent PI3K inhibitors with antiproliferative activity

Cinnoline is a potential pharmacophore which has rarely been reported for uses as PI3K inhibitors. In this study, a series of cinnoline derivatives were developed as PI3K inhibitors and evaluated for enzymatic and cellular activities. Most compounds displ

Experimental and Computational Studies on Cp*CyRh(III)/KOPiv-Catalyzed Intramolecular Dehydrogenative Cross-Couplings for Building Eight-Membered Sultam/Lactam Frameworks

Described herein is an unusual Cp*CyRh(III)-catalyzed intramolecular site-specific aryl C-H annulation, a highly chemoselective protocol providing direct access to eight-membered sultams/lactams with broad substrate/functional group tolerance. Experimental and computational studies reveal that such a transformation involves a unique PivOH-assisted aryl C-H activation/alkene insertion/β-H elimination/hydrogen-transfer process involving the Rh(III)-hydride species as the active intermediate with the concomitant release of H2 as the major byproduct, thus enabling the developed Cp*CyRh(III) catalysis with redox-neutral and highly atom-economical features.

One-Pot Synthesis of Spirocyclopenta[ a]indene Derivatives via a Cascade Ring Expansion and Intramolecular Friedel-Crafts-Type Cyclization

A one-pot efficient synthetic approach for the rapid construction of spirocyclopenta[a]indene derivatives has been developed via an iodine-initiated cascade ring expansion and intramolecular Friedel-Crafts-type cyclization from propargyl alcohol-tethered alkylidenecyclobutanes under mild conditions with broad substrate scope. This cascade process can be elegantly conducted on a gram scale. A plausible reaction mechanism has been proposed on the basis of a series of deuterium labeling and control experiments.

Novel 4-(1H-1,2,3-triazol-4-yl)methoxy)cinnolines as potent antibacterial agents: Synthesis and molecular docking study

A new series of cinnoline-1,2,3-triazole derivatives were designed and synthesized by adopting Cu(1) catalyzed regeoselective1,3-dipolar cycloaddition reaction of terminal alkyne and azide. The in vitro antibacterial activity of all these compounds revealed that compounds 9d, 10a, 10b, and 10c are more potent antibacterial agents. Among the series, compound 4-(3-(4-((cinnolin-4-yloxy)methyl)-1H-1,2,3-triazol-1-yl)propyl)morpholine (10b) exhibited the most potent antibacterial activity against all tested gram-positive and gram-negative bacterial strains. Furthermore, molecular docking studies were also performed to understand the binding interactions of the most active analogs 9d, 10a, 10b, and 10c with Elastase of Pseudomonas aeruginosa (PDB: 1U4G). The results indicated that these classes of compounds have potential antibacterial activity, especially the compound 10b may serve as a promising antibacterial lead compound that could be further optimized for the further development of antibacterial drugs.

Pd-catalyzed regiodivergent synthesis of diverse oxindoles enabled by the versatile heck reaction of carbamoyl chlorides

We report herein a miscellaneous oxindole synthesis bearing an all-carbon quaternary center, enabled by Pd-catalyzed intramolecular cyclization followed by multiple intermolecular Heck reactions of both easily accessible alkene-tethered carbamoyl chlorides and olefins. This protocol obviates the use of prefunctionalized olefinic reagents, exhibits excellent functional group tolerance, and features fascinating reactive versatility.

SUBSTITUTED IMIDAZOLES FOR THE INHIBITION OF TGF-BETA AND METHODS OF TREATMENT

This disclosure relates to low molecular weight substituted imidazoles that inhibit the TGF-b signaling pathway. More specifically, this disclosure relates to methods of using said imidazoles for the treatment of diseases related to the TGF-b signaling pathways including, but not limited to, atherosclerosis, Marfan syndrome, Loeys-Dietz syndrome, obesity, diabetes, multiple sclerosis, keratoconus, idiopathic pulmonary fibrosis, Alzheimer's Disease, chronic kidney disease, and scleroderma.

The Reaction of o-Aminoacetophenone N-Tosylhydrazone and CO2 toward 1,4-Dihydro-2H-3,1-benzoxazin-2-ones

A transition-metal-free reaction of o-aminoacetophenone N-tosylhydrazone and CO2 has been developed, leading to a series of 1,4-dihydro-2H-3,1-benzoxazin-2-ones in moderate to good yields. This procedure proceeds with the sequential fixation of CO2 by amino leading to carbamic acid and the intra- molecular insertion of hydroxyl to carbene. (Figure presented.).