29124-56-9

Basic information

• Product Name: 1-(2-amino-5-bromophenyl)ethanone
• Synonyms: 1-(2-amino-5-bromophenyl)ethanone;2'-Amino-5'-bromoacetophenone;1-(2-aMino-5-broMophenyl)ethan-1-one
• CAS NO: 29124-56-9
• Molecular Formula: C₈H₈BrNO
• Molecular Weight: 214.06
• Mol File: 29124-56-9.mol
• Article Data: 46

Chemical Properties

• Melting Point: 86-88 °C
• Boiling Point: 302.244 °C at 760 mmHg
• Flash Point: 136.592 °C
• Appearance: /
• Density: 1.535 g/cm³
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: 1.60±0.10(Predicted)
• CAS DataBase Reference: 1-(2-amino-5-bromophenyl)ethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-amino-5-bromophenyl)ethanone(29124-56-9)
• EPA Substance Registry System: 1-(2-amino-5-bromophenyl)ethanone(29124-56-9)

Safety Data

• Hazardous Substances Data: 29124-56-9(Hazardous Substances Data)

Usage

General Description

1-(2-amino-5-bromophenyl)ethanone is a chemical compound with the chemical formula C8H8BrNO. It is an organic ketone that contains a bromine atom, an amino group, and a phenyl group. 1-(2-amino-5-bromophenyl)ethanone is commonly used in organic synthesis and pharmaceutical research as a key intermediate for the synthesis of various drugs. It has also shown potential as a building block for the development of new materials and has been used in the production of dyes and other organic compounds. Due to its unique structure and functional groups, 1-(2-amino-5-bromophenyl)ethanone has been the subject of numerous studies and research efforts aiming to explore its potential applications in various fields.

Upstream product

• 39263-32-6 2-amino-5-bromobenzonitrile 
• 1885-29-6 anthranilic acid nitrile 
• 75-16-1 methylmagnesium bromide 
• 41877-24-1 1-(5-bromo-2-nitrophenyl)ethane-1-one 
• 2142-63-4 1-(3-Bromophenyl)ethanone 
• 676-58-4 methylmagnesium chloride 
• 304854-54-4 2-amino-5-bromo-N-methoxy-N-methyl-benzamide 
• 613-89-8 2-Aminoacetophenone 
• 917-54-4 methyllithium 
• 5794-88-7 5-Bromo-2-aminobenzoic acid 
• 5234-26-4 N-(2-acetylphenyl)acetamide 
• 75-05-8 acetonitrile 
• 106-40-1 4-bromo-aniline 
• 617-35-6 2-oxo-propionic acid ethyl ester 

Downstream Products

• 1020576-91-3 ethyl 2-((2-acetyl-4-bromophenyl)amino)-2-oxoacetate 
• 937817-49-7 (2-acetyl-4-bromophenylamino)acetic acid ethyl ester 
• 29124-64-9 N-(2-acetyl-4-bromophenyl)acetamide 
• 194782-61-1 4-bromo-2-(prop-1-en-2-yl)aniline 
• 90725-49-8 5-bromo-3-methyl-1,3-dihydro-indol-2-one 
• 552331-16-5 5-bromo-3-methyl-1H-indazole 
• 1337558-28-7 ethyl 6-bromo-4-oxo-1H-cinnoline-3-carboxylate 
• 1020576-84-4 6-[4-({[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methyl}oxy)phenyl]-4-methyl-2-quinazolinecarboxylic acid 
• 1020577-05-2 ethyl 6-[4-({[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methyl}oxy)phenyl]-4-methyl-2-quinazolinecarboxylate 
• 1197943-70-6 1-(2-amino-5-bromo-3-chlorophenyl)ethan-1-one 
• 1160304-69-7 1-(2-amino-5-bromophenyl)ethanone O-phenyl oxime 
• 304853-89-2 2-(2-amino-5-bromophenyl)-propan-2-ol 
• 865670-86-6 1-(2-amino-5-bromophenyl)-1-thien-3-ylethanol 
• 865670-82-2 1-(2-amino-5-bromophenyl)-1-(2-furyl)ethanol 

Relevant articles and documents

In vitro cytotoxicity of novel 2,5,7-tricarbo-substituted indoles derived from 2-amino-5-bromo-3-iodoacetophenone

A series of novel 2,5,7-tricarbo-substituted indoles were prepared via sequential Sonogashira and Suzuki–Miyaura cross-coupling of 2-amino-5-bromo-3-iodoacetophenone with terminal acetylenes and aryl/styrylboronic acids followed by palladium chloride-medi

Discovery of cinnoline derivatives as potent PI3K inhibitors with antiproliferative activity

Cinnoline is a potential pharmacophore which has rarely been reported for uses as PI3K inhibitors. In this study, a series of cinnoline derivatives were developed as PI3K inhibitors and evaluated for enzymatic and cellular activities. Most compounds displ

Experimental and Computational Studies on Cp*CyRh(III)/KOPiv-Catalyzed Intramolecular Dehydrogenative Cross-Couplings for Building Eight-Membered Sultam/Lactam Frameworks

Described herein is an unusual Cp*CyRh(III)-catalyzed intramolecular site-specific aryl C-H annulation, a highly chemoselective protocol providing direct access to eight-membered sultams/lactams with broad substrate/functional group tolerance. Experimental and computational studies reveal that such a transformation involves a unique PivOH-assisted aryl C-H activation/alkene insertion/β-H elimination/hydrogen-transfer process involving the Rh(III)-hydride species as the active intermediate with the concomitant release of H2 as the major byproduct, thus enabling the developed Cp*CyRh(III) catalysis with redox-neutral and highly atom-economical features.

Novel 4-(1H-1,2,3-triazol-4-yl)methoxy)cinnolines as potent antibacterial agents: Synthesis and molecular docking study

A new series of cinnoline-1,2,3-triazole derivatives were designed and synthesized by adopting Cu(1) catalyzed regeoselective1,3-dipolar cycloaddition reaction of terminal alkyne and azide. The in vitro antibacterial activity of all these compounds revealed that compounds 9d, 10a, 10b, and 10c are more potent antibacterial agents. Among the series, compound 4-(3-(4-((cinnolin-4-yloxy)methyl)-1H-1,2,3-triazol-1-yl)propyl)morpholine (10b) exhibited the most potent antibacterial activity against all tested gram-positive and gram-negative bacterial strains. Furthermore, molecular docking studies were also performed to understand the binding interactions of the most active analogs 9d, 10a, 10b, and 10c with Elastase of Pseudomonas aeruginosa (PDB: 1U4G). The results indicated that these classes of compounds have potential antibacterial activity, especially the compound 10b may serve as a promising antibacterial lead compound that could be further optimized for the further development of antibacterial drugs.